Postpartum maternal exposure to predator odor alters offspring antipredator behavior, basal HPA axis activity and immunoglobulin levels in adult Brandt’s voles
Postpartum maternal exposure to predator odor alters offspring antipredator behavior, basal HPA axis activity and immunoglobulin levels in adult Brandt’s voles
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产后母体暴露于捕食者气味会改变成年布氏田鼠的后代抗捕食者行为、基础 HPA 轴活性和免疫球蛋白水平
DOI：
10.1016/j.bbr.2021.113532
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发表时间：
2021-08
影响因子：
2.7
通讯作者：
Wanhong Wei
中科院分区：
文献类型：
--
作者：
Ruiyong Wu;Shan Li;Yefeng Huang;Jinyue Pang;Yongjian Cai;Xinyue Zhang;Tianyi Jiang;Shengmei Yang;Wanhong Wei
捕食风险可以通过母体效应影响后代的行为、生理和健康，但大多数研究主要集中在怀孕期间的这种影响；关于产后捕食风险对后代表型的影响，我们知之甚少。在这里，我们比较了雌性勃兰特田鼠（Lasiopodomys brandtii）在产后1-18天每天暴露于猫气味（CO）、兔子气味（RO）和蒸馏水（DW）三种处理之一60分钟后所产生的成年后代（大约90天大）的反捕食者行为。同时测定血浆促肾上腺皮质激素（ACTH）、皮质酮（CORT）、下丘脑促肾上腺皮质激素释放激素（CRH）以及脾脏免疫球蛋白（IgA、IgM、IgG）的基础水平。我们的数据显示，CO暴露母亲的后代在急性15分钟CO暴露下表现出较少的头出行为，而雌性后代表现出更多的冻结行为。CO后代的ACTH和CORT水平明显低于RO和DW后代。此外，雌性而非雄性CO后代的下丘脑CRH表达和脾脏IgG水平高于对照组，显示出性别特异性效应。这些研究结果表明，产后母亲捕食风险暴露会促进成年后代对这些线索的被动回避反应，显示出产后捕食风险的跨代母亲效应。此外，这些变化可能与下丘脑-垂体-肾上腺轴和免疫功能的改变有关。
Predation risk can program offspring behavior, physiology, and fitness through maternal effect, but most studies have mainly focused on this effect during pregnancy; little is known about the effect of postpartum predation risk on offspring’s phenotype. Here, we compared the antipredator behaviors of adult offspring (approximately 90 days old) produced by female Brandt’s voles (Lasiopodomys brandtii) exposed to one of three treatments: cat odor (CO), rabbit odor (RO), and distilled water (DW) for 60 min daily from postpartum day 1–18. Basal levels of plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT), hypothalamic corticotrophin releasing hormone (CRH), as well as spleen immunoglobulins (IgA, IgM, and IgG) were also measured. Our data showed that the offspring of CO-exposed mothers displayed less head-out behavior to acute 15-min CO exposure, and female offspring showed more freezing behavior. CO offspring showed significantly lower basal ACTH and CORT levels than the RO and DW offspring. Additionally, female but not male CO offspring had higher hypothalamic CRH expression and spleen IgG levels than controls, showing a sex-specific effect. These findings demonstrate that postpartum maternal predator risk exposure promotes a passive-avoidant response to these cues in adult offspring, showing a cross-generational maternal effect of postpartum predation risk. Further, these changes may be associated with alterations in the hypothalamic-pituitary-adrenal axis and immune function.