Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
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DOI：
10.1038/nn.4163
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发表时间：
2015-12-01
影响因子：
25
通讯作者：
Konnerth, Arthur
中科院分区：
文献类型：
--
作者：
Busche, Marc Aurel;Grienberger, Christine;Konnerth, Arthur
Among the most promising approaches for treating Alzheimer's disease is immunotherapy with amyloid-beta (A beta)-targeting antibodies. Using in vivo two-photon imaging in mouse models, we found that two different antibodies to A beta used for treatment were ineffective at repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This unexpected finding provides a possible cellular explanation for the lack of cognitive improvement by immunotherapy in human studies.
