OBESITY, INSULIN-RESISTANCE, AND ITS LINK TO NON-INSULIN-DEPENDENT DIABETES-MELLITUS
OBESITY, INSULIN-RESISTANCE, AND ITS LINK TO NON-INSULIN-DEPENDENT DIABETES-MELLITUS
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DOI：
10.1016/0026-0495(95)90314-3
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发表时间：
1995-09-01
影响因子：
9.8
通讯作者：
WALKER, M
中科院分区：
文献类型：
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作者：
WALKER, M
研究表明，肥胖患者对胰岛素的组织反应比瘦人低，这表明肥胖促进了胰岛素抵抗的发展。肥胖和胰岛素抵抗之间的联系机制尚不清楚，与瘦人相比，肥胖患者的葡萄糖氧化降低，脂质氧化增加，并且高胰岛素血症，这可能导致胰岛素受体的下调。对健康受试者的研究表明，血浆非酯化游离脂肪酸水平升高导致外周胰岛素诱导的葡萄糖摄取减少。肥胖患者血浆非酯化游离脂肪酸水平升高，这可能与胰岛素抵抗的发展有关，中心性肥胖患者外周血管胰岛素抵抗程度更高，血浆胰岛素水平高于下体肥胖患者，非胰岛素依赖型糖尿病（NIDDM）患者肥胖后胰岛素敏感性进一步降低。对皮马印第安人的研究表明，在父母中至少有一方患有糖尿病的儿童中，肥胖是NIDDM最重要的预测因素，肥胖患者的胰岛素敏感性随着体重减轻而改善。版权所有(C) 1995由W，B。桑德斯公司
Studies have shown that obese patients have a lower tissue response to insulin than lean individuals, suggesting that obesity promotes the development of insulin resistance. The mechanisms linking obesity and insulin resistance are not known, Obese patients have decreased glucose oxidation and increased lipid oxidation compared with lean individuals, and are hyperinsulinemic, which may result in downregulation of insulin receptors, Studies in healthy subjects have shown that increased plasma levels of nonesterified free fatty acids resulted in a decrease in peripheral insulin-induced glucose uptake, Obese patients have increased plasma levels of nonesterified free fatty acids, which may be involved in the development of insulin resistance, Patients with central obesity have a greater degree of peripheral insulin resistance and higher plasma insulin levels than patients with lower body obesity, Patients with non-insulin-dependent diabetes mellitus (NIDDM) who become obese have a further reduction in insulin sensitivity. Studies in Pima Indians have shown that adiposity is the most important predictor for NIDDM in children with at least one parent who have diabetes, Insulin sensitivity improves with weight loss in obese patients. Copyright (C) 1995 by W,B. Saunders Company