Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin.
Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin.
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DOI：
10.2147/cia.s33165
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发表时间：
2012
影响因子：
3.6
通讯作者：
Nakayama J
中科院分区：
文献类型：
--
作者：
Furumura M;Sato N;Kusaba N;Takagaki K;Nakayama J
法国海松皮提取物（PBE）由于其富含多酚的成分，已成为治疗各种疾病的膳食补充剂。低聚原花青素（OPCs）是一类生物类黄酮复合物，富含法国海产PBE，具有抗氧化和抗炎活性。先前的研究表明，法国海上PBE有助于减少紫外线辐射对皮肤的伤害，并可能保护人类面部皮肤免受光老化的症状。为了评价法国海产PBE改善面部光损伤皮肤的临床疗效，我们进行了一项口服补充PBE的随机试验。112名患有轻度至中度皮肤光老化的女性被随机分为两组，一组是12周的开放试验方案，每天补充100毫克PBE，另一组是平行组试验方案，每天补充40毫克PBE。在每天100毫克和40毫克PBE补充方案的两个时间疗程中，皮肤光老化评分的临床分级均显着降低。利用皮肤颜色测量也证明了老年斑色素沉着的显著减少。PBE可显著改善光损伤皮肤的临床表现。我们的研究结果证实了PBE的有效性和安全性。
French maritime pine bark extract (PBE) has gained popularity as a dietary supplement in the treatment of various diseases due to its polyphenol-rich ingredients. Oligometric proanthocyanidins (OPCs), a class of bioflavonoid complexes, are enriched in French maritime PBE and have antioxidant and anti-inflammatory activity. Previous studies have suggested that French maritime PBE helps reduce ultraviolet radiation damage to the skin and may protect human facial skin from symptoms of photoaging. To evaluate the clinical efficacy of French maritime PBE in the improvement of photodamaged facial skin, we conducted a randomized trial of oral supplementation with PBE. One hundred and twelve women with mild to moderate photoaging of the skin were randomized to either a 12-week open trial regimen of 100 mg PBE supplementation once daily or to a parallel-group trial regimen of 40 mg PBE supplementation once daily. A significant decrease in clinical grading of skin photoaging scores was observed in both time courses of 100 mg daily and 40 mg daily PBE supplementation regimens. A significant reduction in the pigmentation of age spots was also demonstrated utilizing skin color measurements. Clinically significant improvement in photodamaged skin could be achieved with PBE. Our findings confirm the efficacy and safety of PBE.