OSTEOLYSIS IN FROG - EFFECTS OF PARATHORMONE
OSTEOLYSIS IN FROG - EFFECTS OF PARATHORMONE
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DOI：
10.1139/y66-114
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发表时间：
1966-01-01
影响因子：
2.1
通讯作者：
DROUIN, P
中科院分区：
文献类型：
--
作者：
BELANGER, LF;DROUIN, P
用18至54单位剂量的哺乳动物甲状旁腺提取物（Para-Thor-Mone，Lilly）腹膜内处理的牛蛙蝌蚪经历骨质溶解，其特征在于成熟骨细胞周围的无机盐和有机基质的损失、基质中的异染性变化和蛋白酶的产生。与此同时，成熟的骺软骨部分丢失，可能是通过局部蛋白水解活性。胶原酶的吸收在3天内加速了40%。
Tadpoles of Rana catesbeiana treated intraperitoneally with doses of 18 to 54 units of mammalian parathyroid extract (Para-Thor-Mone, Lilly) underwent osteolysis as characterized by loss of mineral salt and organic matrix around mature osteocytes, metachromatic changes in the matrix, and production of protease. At the same time, the mature epiphyseal cartilage was lost in part, presumably through local proteolytic activity. The collagenase resorption of the tail was accelerated by 40% in 3 days.