FATTY-ACIDS IN CELL SIGNALING - MODULATION BY LIPID-BINDING PROTEINS
FATTY-ACIDS IN CELL SIGNALING - MODULATION BY LIPID-BINDING PROTEINS
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DOI：
10.1016/0952-3278(95)90010-1
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发表时间：
1995-02-01
影响因子：
3
通讯作者：
VANDERVUSSE, GJ
中科院分区：
文献类型：
--
作者：
GLATZ, JFC;BORCHERS, T;VANDERVUSSE, GJ
长链脂肪酸和它们的几种代谢产物现在已经被证明作为初级或次级信使参与特定的细胞信号传导途径。鉴于其极低的水溶性，这些化合物的细胞外以及细胞内转运被认为是由特定的脂质结合蛋白，如细胞质脂肪酸结合蛋白（FABP）促进。本文综述了细胞内脂质结合蛋白在脂肪酸介导的信号转导通路中的生物学意义和可能的调节作用。
Long-chain fatty acids and several of their metabolites have now been shown to be involved as primary or secondary messengers in specific cell signalling pathways. In view of their extremely low aqueous solubility, the extracellular as well as intracellular transport of these compounds is assumed to be facilitated by specific lipid binding proteins, such as cytoplasmic fatty acid-binding protein (FABP). In this paper a survey is given on the biological significance and possible modulatory action of intracellular lipid binding proteins for fatty acid-mediated signal transduction pathways.