The effect of crude drugs on the angiogenic property and dynamic viscoelasticity of PEMA-based soft polymer materials.
The effect of crude drugs on the angiogenic property and dynamic viscoelasticity of PEMA-based soft polymer materials.
复制标题
生药对PEMA基软质高分子材料血管生成性能和动态粘弹性的影响
DOI：
10.4012/dmj.2016-387
复制
发表时间：
2017
影响因子：
2.5
通讯作者：
K. Sasaki
中科院分区：
文献类型：
--
作者：
Wei;G. Hong;Jian;H. Murata;K. Sasaki
本研究旨在研究生药对软质高分子材料动态粘弹性和血管生成性能的影响。以两种聚甲基丙烯酸酯和药材黄芪（Astragalus membranaceus Bunge [HQ]）和丹参（Salvia dantiorrhiza Bunge [DS]）为粉末。柠檬酸乙酰三丁酯和乙醇以液体形式使用。分别在蒸馏水中浸泡0、1、3、7、14、28天后测定各试样的动态粘弹性。使用CellPlayer血管生成PrimeKit检测血管生成。不同材料的动态粘弹性有显著差异。含有1 wt% HQ的标本比含有5 wt%和10 wt% HQ和DS的标本具有更高的血管生成活性。我们的研究结果表明，在软质高分子材料中添加少量的生药可以促进人体组织的血管生成。
This study aimed to determine the effect of crude drugs on the dynamic viscoelasticity and angiogenic property of soft polymer materials, in vitro. Two kinds of polyethyl methacrylates, and crude drugs (Astragalus membranaceus Bunge [HQ] and Salvia miltiorrhiza Bunge [DS]) were used in their powdered forms. And, acetyl tributyl citrate and ethyl alcohol were used in the liquid form. The dynamic viscoelasticity of each specimen was measured after 0, 1, 3, 7, 14 and 28 days of immersion in distilled water. The CellPlayer angiogenesis PrimeKit assay was used to test angiogenesis. Significant differences in dynamic viscoelasticity were observed among the materials. Specimens containing 1 wt% HQ showed higher angiogenic activity than those containing 5 wt% and 10 wt% HQ, and DS. Our results suggest that the addition of low amounts of crude drugs to soft polymer materials may promote angiogenesis in human tissues.
含己二酸酯和马来酸酯增塑剂的软质丙烯酸树脂材料的动态粘弹性和吸水特性
影响因子：
2.5
作者：
G. Hong;H. Tsuka;T. Maeda;Y. Akagawa;K. Sasaki
通讯作者：
K. Sasaki