Risk assessment and genetic counseling for hereditary breast and ovarian cancer: recommendations of the National Society of Genetic Counselors.
Risk assessment and genetic counseling for hereditary breast and ovarian cancer: recommendations of the National Society of Genetic Counselors.
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DOI：
10.1007/s10897-007-9090-7
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发表时间：
2007-06-01
影响因子：
1.9
通讯作者：
Fay, Angela Musial
中科院分区：
文献类型：
--
作者：
Berliner, Janice L;Fay, Angela Musial
这些癌症遗传咨询建议描述了通过癌症风险评估识别遗传性乳腺癌和卵巢癌(HBOC)高危个体的医疗、心理和伦理影响，无论是否进行遗传易感性测试。它们是由全国遗传咨询师协会家族性癌症风险咨询特别兴趣小组实践问题小组的成员开发的。本文件中包含的信息来源于对当前癌症遗传风险评估文献的广泛回顾，以及在遗传性乳腺癌和卵巢癌的教育和咨询方面具有丰富经验的遗传咨询师的专业知识。这一过程的关键组成部分包括确定病史和家族史、癌症风险的确定和沟通、风险认知评估、关于HBOC遗传学的教育、适当情况下对HBOC进行分子检测的讨论(包括益处、风险和限制)以及任何必要的后续行动。这些建议并不规定一个专属的管理过程，也不保证一个具体的结果。此外，它们不会取代卫生保健提供者基于客户的临床情况的专业判断。
These cancer genetic counseling recommendations describe the medical, psychosocial and ethical implications of identifying at-risk individuals for hereditary breast and ovarian cancer (HBOC) through cancer risk assessment, with or without genetic susceptibility testing. They were developed by members of the Practice Issues Subcommittee of the National Society of Genetic Counselors' Familial Cancer Risk Counseling Special Interest Group. The information contained in this document is derived from extensive review of the current literature on cancer genetic risk assessment as well as the professional expertise of genetic counselors with significant experience in education and counseling regarding hereditary breast and ovarian cancer. Critical components of the process include the ascertainment of medical and family histories, determination and communication of cancer risk, assessment of risk perception, education regarding the genetics of HBOC, discussion of molecular testing for HBOC if appropriate (including benefits, risks and limitations) and any necessary follow-up. These recommendations do not dictate an exclusive course of management or guarantee a specific outcome. Moreover, they do not replace the professional judgment of a health care provider based on the clinical situation of a client.