Fat Mass Is Inversely Associated with Serum Carboxymethyl-Lysine, An Advanced Glycation End Product, in Adults
Fat Mass Is Inversely Associated with Serum Carboxymethyl-Lysine, An Advanced Glycation End Product, in Adults
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DOI：
10.3945/jn.111.143172
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发表时间：
2011-09-01
影响因子：
4.2
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Semba, Richard D.;Arab, Lenore;Ferrucci, Luigi
高水平的循环晚期糖基化终产物（AGE）与心血管疾病、糖尿病、慢性肾脏疾病和死亡率增加有关，但影响循环AGE水平的因素尚不清楚。我们的目的是描述血清羧甲基赖氨酸（CML），一个主要的循环AGE，和成人的身体组成之间的关系。在一项横断面研究中，对来自巴尔的摩老龄化纵向研究的592名年龄在26-93岁的成年人进行全身DXA和血清CM L测量。中位（第25百分位数，第75百分位数）CML浓度为2.26（1.86，2.67）μ mol/L。总脂肪量[β = -0.17（95% CI-0.10，-0.24）; P < 0.0001]，躯干脂肪量[β = -0.17（95% CI-0.10，-0.25）; P< 0.0001]，和无脂肪质量[β = -0.13（95% CI-0.05，-0.20）; P = 0.001]在单独的多变量线性回归模型中，每1 SD增加与血清CML呈负相关，调整了年龄、性别、BMI、收缩压，TG、HDL胆固醇和肾功能。瘦体重与血清CML无独立相关性。这些发现表明，血清CML浓度强烈受体脂的影响，可能是因为CML是优先沉积在脂肪组织或因为脂肪细胞影响AGE的代谢。J.营养141：1726-1730，2011.
High levels of circulating advanced glycation end products (AGE) are associated with cardiovascular disease, diabetes, chronic kidney disease, and increased mortality, but factors that influence levels of circulating AGE are not well known. Our objective was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and body composition in adults. In a cross-sectional study, total body DXA was performed and serum CM L was measured in 592 adults, aged 26-93 y, from the Baltimore Longitudinal Study of Aging. Median (25th, 75th percentile) CML concentrations were 2.26 (1.86, 2.67) mu mol/L. Total fat mass [beta = -0.17(95% CI -0.10, -0.24); P < 0.0001], truncal fat mass [beta = -0.17(95% CI -0.10, -0.25); P< 0.0001], and appendicular fat mass [beta = -0.13 (95% CI -0.05, -0.20); P = 0.001] per 1 SD increase were inversely associated with serum CML in separate multivariate linear regression models, adjusting for age, sex, BMI, systolic blood pressure, TG, HDL cholesterol, and renal function. Lean body mass was not independently associated with serum CML. These findings suggest that serum CML concentration is strongly affected by body fat, possibly because CML is preferentially deposited in fat tissue or because adipocytes affect the metabolism of AGE. J. Nutr. 141: 1726-1730, 2011.