Oxidoreductase-Initiated Radical Polymerizations to Design Hydrogels and Micro/Nanogels: Mechanism, Molding, and Applications
Oxidoreductase-Initiated Radical Polymerizations to Design Hydrogels and Micro/Nanogels: Mechanism, Molding, and Applications
复制标题
氧化还原酶引发自由基聚合来设计水凝胶和微/纳米凝胶：机制、成型和应用
DOI：
10.1002/adma.201705668
复制
发表时间：
2018
影响因子：
29.4
通讯作者：
Wang Qigang
中科院分区：
文献类型：
--
作者：
Wang Xia;Chen Shuangshuang;Wu Dongbei;Wu Qing;Wei Qingcong;He Bin;Lu Qinghua;Wang Qigang
由于其三维交联网络和可调的物理化学性质，不同尺寸的聚合物水凝胶广泛应用于组织工程、药物递送系统、污染调节、离子导电电解质、农业抗旱、化妆品和食品工业。新型的、环境友好的、高效的氧化还原酶引发的自由基聚合来设计水凝胶和微/纳米凝胶已经得到越来越多的关注。本文综述了近年来新型酶引发体系在水凝胶聚合中的应用，包括聚合物网络和杂化聚合物网络的聚合机理和成型方法。作为一种新兴的引发方法，介绍了界面酶促聚合制备微/纳米杂化凝胶的初步进展。此外，在组织工程，生物成像和治疗的某些生物学应用逐步证明。最后，酶形成的水凝胶，新的酶系统，和潜在的治疗诊断应用的安全性方面的一些观点进行了讨论。
Due to their 3D cross‐linked networks and tunable physicochemical properties, polymer hydrogels with different sizes are applied widely in tissue engineering, drug‐delivery systems, pollution regulation, ionic conducting electrolytes, agricultural drought‐resistance, cosmetics, and the food industry. Novel, environmentally friendly, and efficient oxidoreductase‐initiated radical polymerizations to design hydrogels and micro/nanogels have gained increasing attention. Herein, the recent advances on the use of novel enzyme‐initiated systems for hydrogel polymerization, including the mechanisms, and molding of polymeric and hybrid‐polymeric networks are reviewed. Preliminary progress related to interfacial enzymatic polymerization for the generation of hybrid micro/nanogels is introduced as an emerging initiating approach. In addition, certain biological applications in tissue engineering, bioimaging, and therapy are demonstrated step by step. Finally, some perspectives on the safety profile of enzymatic formed hydrogels, new enzymatic systems, and potential theranostic applications are discussed.