Signaling endosome hypothesis: A cellular mechanism for long distance communication
Signaling endosome hypothesis: A cellular mechanism for long distance communication
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DOI：
10.1002/neu.10323
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发表时间：
2004-02-05
期刊：
影响因子：
--
通讯作者：
Mobley, WC
中科院分区：
文献类型：
--
作者：
Howe, CL;Mobley, WC
分析了信号内体沿轴突逆行运输的动力学，并提供了证据，证明即使在相对较小的距离内，这种运输系统也比基于扩散或钙波的信号系统更有效。提供了支持信号内体假说的证据，并将该假说扩展到包括许多细胞类型和多个细胞维度的信号。最后，提供了一个跳跃的、再生的肌醇1，4，5-三磷酸的波模型，以协调文献中关于基于内体的逆行信号的当前差异。(C)2003年威利期刊公司。
The kinetics of signaling endosome retrograde transport along axons is analyzed and offered as evidence that such transport is more efficient than diffusion or calcium wave-based signaling systems over even relatively small distances. Evidence is provided to support the signaling endosome hypothesis and to expand the hypothesis to include signaling in many cell types and many cellular dimensions. Finally, a saltatory, regenerating inositol 1,4,5-trisphosphate wave model is offered to reconcile current discrepancies in the literature regarding endosomal-based retrograde signaling. (C) 2003 Wiley Periodicals, Inc.