The gene for the APC-binding protein beta-catenin (CTNNB1) maps to chromosome 3p22, a region frequently altered in human malignancies.
The gene for the APC-binding protein beta-catenin (CTNNB1) maps to chromosome 3p22, a region frequently altered in human malignancies.
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APC 结合蛋白 β-连环蛋白 (CTNNB1) 的基因定位于染色体 3p22，该区域在人类恶性肿瘤中经常发生变化。
DOI：
10.1159/000134136
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kinzler,KW
中科院分区：
文献类型：
--
作者：
Trent,JM;Wiltshire,R;Su,LK;Nicolaides,NC;Vogelstein,B;Kinzler,KW
β-连环蛋白（β-Catenin，β-Catenin）是E-钙粘蛋白（E-cadherin，E-cadherin）相关蛋白，参与细胞粘附过程。它最近被证明与APC蛋白相互作用，已知APC蛋白的基因在家族性腺瘤性息肉病患者的生殖系中发生突变。这种相互作用意味着β-catenin是APC基因的潜在调节因子。通过荧光原位杂交（FISH）将人β-连环蛋白基因（CTNNB 1）定位于染色体3 p22，将该基因与几种人类恶性肿瘤中经常改变的区域联系起来。基因和蛋白质相互作用的位置表明β-连环蛋白在各种人类癌症的病因学中的重要性。
β-Catenin is one of the E-cadherin associated proteins involved in the process of cellular adhesion. It has recently been shown to interact with the APC protein whose gene is known to be mutated in the germline of familial adenomatous polyposis patients. This interaction implies that β-catenin is a potential regulator of the APC gene. The localization of the human β-catenin gene (CTNNB1) to chromosome 3p22, by fluorescent in situ hybridization (FISH), has linked the gene to a region that is frequently altered in several human malignancies. The location of the gene and the protein interactions suggest the importance of β-catenin in the etiology of various human cancers.