Levosimendan vs dobutamine in septic shock
Levosimendan vs dobutamine in septic shock
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DOI：
10.1016/j.jcrc.2009.06.006
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发表时间：
2009-09-01
影响因子：
3.7
通讯作者：
Shalabi, Sanaa A.
中科院分区：
文献类型：
--
作者：
Alhashemi, Jamal A.;Alotaibi, Qamar A.;Shalabi, Sanaa A.
左西孟旦是一种钙敏化剂，可增加心肌收缩力而不增加细胞内钙水平。其疗效已在急性失代偿性心力衰竭中得到证实，但尚未在严重脓毒症/脓毒性休克中进行评估。我们假设左西孟旦会增加严重脓毒症/感染性休克患者的中心静脉饱和度（ScvO2）并降低血清乳酸水平。
Levosimendan is a calcium sensitizer that increases cardiac contractility without increasing intracellular calcium levels. Its efficacy has been demonstrated in acute decompensated heart failure but has not been evaluated in severe sepsis/septic shock. We hypothesized that levosimendan increases central venous saturation (ScvO2) and decreases serum lactate levels in patients with severe sepsis/septic shock.