Cell biology and evolution: molecular modules link it all?
Cell biology and evolution: molecular modules link it all?
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细胞生物学和进化：分子模块将这一切联系起来？
DOI：
10.1016/j.bbagrm.2008.09.004
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Brauchle,Michael
中科院分区：
文献类型：
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作者：
Brauchle,Michael
比较发育中的胚胎的经典研究表明，修饰的细胞生物学过程在新表型进化中的重要性。在这里，我重新审视这种联系，专注于胚胎发育，特别是线虫胚胎发生。我比较了线虫胚胎发生在两个基本的细胞生物学过程，细胞周期和第一分裂轴的本地化的表型差异。对这些和其他过程的分析表明，在细胞生物学水平上，发现了不一定转化为形态差异的详尽变异。现代分子分析已经导致了这样一种观点，即由蛋白质组或模块组成的分子复合物，它们一起工作，负责细胞生物学程序的正确执行。我将讨论如何这种模块化的架构可以促进细胞生物学过程中观察到的表型变化。最终，了解细胞行为和表型结果之间的联系将进一步阐明表型进化的机制。
Classical studies comparing developing embryos have suggested the importance of modified cell biological processes in the evolution of new phenotypes. Here, I revisit this connection focusing on embryonic development, in particular nematode embryogenesis. I compare phenotypic differences in nematode embryogenesis in two basic cell biological processes, the cell cycle and the localization of the first division axis. The analysis of these and other processes shows that, at the cell biological level, exhaustive variation is found that does not necessarily translate into morphological differences. Modern molecular analyses have led to a view in which molecular complexes, made up of groups of proteins, or modules, that are working together, are responsible for the proper execution of cell biological programs. I discuss how this modular architecture could facilitate the phenotypic changes observed in cell biological processes. Ultimately, understanding the connection between cellular behavior and phenotypic outcome will further elucidate the mechanisms responsible for phenotypic evolution.