CT screening for lung cancer: Importance of emphysema for never smokers and smokers
CT screening for lung cancer: Importance of emphysema for never smokers and smokers
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DOI：
10.1016/j.lungcan.2015.01.014
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发表时间：
2015-04-01
期刊：
影响因子：
5.3
通讯作者：
Yankelevitz, David F.
中科院分区：
文献类型：
--
作者：
Henschke, Claudia I.;Yip, Rowena;Yankelevitz, David F.
用途：根据吸烟史、年龄和肺气肿的CT表现，探讨肺癌在高危和低危人群中的患病率。方法：我们回顾了62,124例年龄在40-90岁的当前、既往和从不吸烟者的基线低剂量CF扫描，以确定肺癌的患病率。我们对肺癌的患病率进行了logistic回归分析，以确定肺气肿的优势比（OR），条件是年龄，女性性别和种族。（95% CI：1.3-1.6），既往吸烟者为1.1%（95% CI：1.0-1.2），从不吸烟者为0.4%（95% CI：0.3-0.6）。在当前吸烟者、既往吸烟者和从不吸烟者中，分别有28.5%（6，684）、20.6%（5，422）和1.6%（194）的人患有肺气肿。目前吸烟者中，无肺气肿者的肺癌患病率为1.1%，而有肺气肿者为2.3（比值比[OR] 1.8; 95%置信区间[CI]：1.4-2.2），既往吸烟者的相应差异为0.9% vs 1.8%（OR：1.7; 95% CI：13-2.2），从不吸烟者为0.4% vs.（OR：6.3; 95%CI：2.4-16.9）。在低剂量CT扫描中识别肺气肿会增加肺癌的风险，从不吸烟。(c)2015爱思唯尔爱尔兰有限公司版权所有。
Purpose: To address the prevalence of lung cancer in high and low-risk people according to their smoking history, age, and CT findings of emphysema.Methods: We reviewed the baseline low-dose CF scans of 62,124 current, former and never smokers, aged 40-90 to determine the prevalence of lung cancer. We performed logistic regression analysis of the prevalence of lung cancer to determine the odds ratio (OR) for emphysema, conditionally on age, female gender, and ethnicity.Results: The prevalence of lung cancer was 1.4% (95% CI: 1.3-1.6) for current smokers, 1.1% (95% CI: 1.0-1.2) for former smokers, and 0.4% (95% CI: 0.3-0.6) for never smokers. Emphysema was identified in 28.5% (6,684), 20.6% (5,422), and 1.6% (194) of current, former, and never smokers, respectively. The prevalence of lung cancer among current smokers was 1.1% for those without emphysema vs. 2.3% for those with emphysema (odds ratio [OR] 1.8; 95% confidence interval [CI]: 1.4-2.2) and the corresponding difference for former smokers was 0.9% vs. 1.8% (OR: 1.7; 95% CI: 13-2.2), and for never smokers, it was 0.4% vs. 2.6% (OR: 6.3; 95% CI: 2.4-16.9).Conclusions: Identification of emphysema in low-dose CT scans increases the risk of lung cancer and is important in determining follow-up of current, former, and never smokers. (c) 2015 Elsevier Ireland Ltd. All rights reserved.