Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
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发表时间：
1983-09
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通讯作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
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作者：
M. Raichle;W. Martin;P. Herscovitch;M. Mintun;J. Markham
我们已经采用了众所周知的组织放射自显影技术测量局部脑血流量（CBF），最初提出的凯蒂和他的同事，用于测量CBF在人类受试者使用正电子发射断层扫描（PET）和静脉注射氧-15-标记水。本报告描述了实施该PET/放射自显影技术所需的步骤。为了建立该方法的准确性，我们测量了CBF与静脉注射氧-15-标记的水和PET在麻醉的成年狒狒，并比较了结果与血流测量的标准示踪剂技术，使用残留检测的一团氧-15-标记的水注入颈内动脉。PET测量的CBF与同一大脑半球的真实CBF之间的相关性非常好。在10-63 ml/（min × 100 g）的血流范围内，CBF（PET）= 0.90 CBF（真实）+ 0.40（n = 23，r = 0.96，p <0.001）。当血流量超过65 ml/（min × 100 g）时，由于已知的脑透水性限制，CBF逐渐被低估。
We have adapted the well-known tissue autoradiographic technique for the measurement of regional cerebral blood flow (CBF), originally proposed by Kety and his colleagues, for the measurement of CBF in human subjects using positron emission tomography (PET) and intravenously administered oxygen-15-labeled water. This report describes the steps necessary for the implementation of this PET/autoradiographic technique. In order to establish the accuracy of the method, we measured CBF with intravenously administered oxygen-15-labeled water and PET in anesthetized adult baboons and compared the results with blood flow measured by a standard tracer technique that uses residue detection of a bolus of oxygen-15-labeled water injected into the internal carotid artery. The correlation between CBF measured with PET and the true CBF for the same cerebral hemisphere was excellent. Over a blood-flow range of 10-63 ml/(min X 100 g), CBF (PET) = 0.90 CBF(true) + 0.40 (n = 23, r = 0.96, p less than 0.001). When blood flow exceeds 65 ml/(min X 100 g) CBF was progressively underestimated due to the known limitation of brain permeability to water.