New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation
New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation
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DOI：
10.1016/j.nuclcard.2004.09.015
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发表时间：
2005-01-01
影响因子：
2.4
通讯作者：
Wackers, FJT
中科院分区：
文献类型：
--
作者：
Liu, YH;Sinusas, AJ;Wackers, FJT
背景。我们之前已经开发了一种新的方法来定量评估左心室（LV）容量和射血分数（EF）从心电图门控单光子发射计算机断层扫描（SPECT）。本研究的目的是介绍方法，验证门控SPECT心脏定量（GSCQ）方法在幽灵和患者中，并确定LVEF的正常值。方法与结果。采用一种简单的阈值分割技术，从非分化的SPECT图像中生成二值图像。采用k均值聚类算法对二值图像进行LV区域与非LV区域的分离。采用基于计数和几何的算法定义心内膜和心外膜边界，计算左室容积和LVEF。gscq量化的体积与实际幻体体积的总体相关性良好（正常幻体r = 0.97，估计标准误差(SEE) = 9.99 mL，有缺陷的幻体r = 0.99, SEE = 6.97 mL）。在患者研究中，SPECT和平衡放射性核素血管造影的GSCQ得出的LVEF也显示出良好的相关性（r = 0.90, SEE = 6.2%）。使用GSCQ从8帧门控SPECT得到的正常LVEF下限为45%。GSCQ法定量大鼠LVEF的效果良好，且不受心肌灌注缺陷或剧烈胃肠活动的影响。GSCQ方法提供了可靠和一致的左室体积和EF评估。与其他方法相比，这种方法受强烈胃肠活动的影响较小。
Background. We have previously developed a new method for quantitative assessment of left ventricular (LV) volumes and ejection fraction (EF) from electrocardiography-gated single photon emission computed tomography (SPECT). The aims of this study were to present the methodology, to validate the gated SPECT cardiac quantification (GSCQ) method in phantoms and patients, and to determine normal values of LVEF.Methods and Results. A simple thresholding technique was used to generate binary images from nongated SPECT images. The K-means cluster classification algorithm was used to separate the LV region from non-LV regions on the binary images. A count- and geometry-based algorithm was applied to define endocardial and epicardial boundaries for calculation of LV volumes and LVEF. Overall correlation between GSCQ-quantified volumes and actual phantom volumes was good (r = 0.97 and standard error of estimation (SEE) = 9.99 mL for normal phantoms, r = 0.99 and SEE = 6.97 mL for phantoms with defects). In patient studies, LVEF derived by GSCQ from SPECT and from equilibrium radionuclide angiography also showed good correlation (r = 0.90 and SEE = 6.2%). The lower limit of normal LVEF from 8-frame gated SPECT by use of GSCQ was 45%. Quantification of LVEF by the GSCQ method was highly producible and was not significantly affected by the presence of myocardial perfusion defects or intense gastrointestinal activity.Conclusions. The GSCQ method provides reliable and consistent assessments of LV volumes and EF. This methodology is less affected by intense gastrointestinal activity than other methods.