Objective measurements of radiotherapy-induced erythema
Objective measurements of radiotherapy-induced erythema
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DOI：
10.1111/j.1600-0846.2004.00078.x
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发表时间：
2004-11-01
影响因子：
2.2
通讯作者：
Franzen, L
中科院分区：
文献类型：
--
作者：
Nyström, J;Geladi, P;Franzen, L
背景/目的：急性放射性红斑的发展是接受放射治疗的患者中的常见现象。由于缺乏可靠的客观分型方法，目前临床上对皮肤反应的程度主要靠主观判断。这激发了目前的初步研究，关于皮肤反应classification.Methods的客观方法的发展的第一步：三个非侵入性技术：近红外（NIR）光谱，激光多普勒灌注成像和数码摄影。近红外光谱分析采用主成分分析（PCA），其他两个结果与传统的单变量方法。对暴露于不同辐射剂量的乳腺癌患者进行了测量。共28例乳腺癌患者参加了1至3次，12例接受4或6 MeV的光子治疗，16例接受10至20 MeV的高能电子治疗，最大剂量为50戈伊.结果：近红外光谱的主成分分析表明，辐射剂量的信息主要存在于第一主成分中。观察到剂量越高，得分值越高。激光多普勒测量的结果表明，在79%的情况下，灌注随辐射剂量显著增加。对数码摄影的分析表明，提出的皮肤发红指数（SRI）随着辐射剂量的增加而增加。然而，在大多数情况下，增长并不显著。通过结合所有数据，相关性辐射剂量被认为是74%的患者参加了一次以上。结论：所有三个非侵入性的方法与辐射剂量，但在不同程度上。近红外光谱，激光多普勒和这三种技术的组合是最有前途的方法表征红斑。
Background/aims: The development of acute radiation erythema is a common phenomenon among patients undergoing radiotherapy treatment. Because of the absence of reliable objective classification methods, the degree of skin reaction can at present mainly be judged subjectively in the clinic. This has motivated the present preliminary study, concerning the first steps in the development of an objective method for skin reaction classification.Methods: Three non-invasive techniques were used: near-infrared (NIR) spectroscopy, laser Doppler perfusion imaging and digital photography. The NIR spectra were analysed with principal component analysis (PCA), and the results from the other two with traditional univariate methods. Measurements were made on breast cancer patients who had been exposed to different irradiation doses. A total of 28 breast cancer patients participated one to three times each; 12 were treated with photons at 4 or 6 MeV and 16 were treated with high-energy electrons between 10 and 20 MeV to a maximum dose of 50 Gy.Results: PCA of NIR spectra shows that information on radiation dose lies mainly in the first principal component. It is observed that the higher the dose the higher the score value. The results from the laser Doppler measurements show that in 79% of the cases the perfusion increases significantly with radiation dose. Analysis of the digital photography shows that a proposed skin redness index (SRI), increases with a higher radiation dose. However, the increase in most cases is not significant. By combining all data, correlation to radiation doses was seen for 74% of the patients who participated more than once.Conclusion: All three non-invasive methods correlate with the radiation dose but to various degrees. NIR spectroscopy, laser Doppler and a combination of the three techniques are the most promising methods for characterising erythema.