Clinically defined vascular depression.
Clinically defined vascular depression.
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DOI：
10.1176/ajp.154.4.562
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发表时间：
1997-04
期刊：
影响因子：
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通讯作者：
G. Alexopoulos;B. Meyers;R. Young;T. Kakuma;D. Silbersweig;M. Charlson
中科院分区：
文献类型：
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作者：
G. Alexopoulos;B. Meyers;R. Young;T. Kakuma;D. Silbersweig;M. Charlson
目的：研究一组有血管性抑郁危险因素的老年抑郁症患者与一组无血管性抑郁危险因素的老年抑郁症患者的临床表现。方法对连续招募的33例血管性抑郁症和32例非血管性抑郁症老年患者进行认知功能障碍、残疾和抑郁症状检查。结果血管性抑郁症患者的总体认知功能障碍和残疾程度高于非血管性抑郁症患者。血管性抑郁症患者的流畅性和命名能力受损更严重，他们有更多的迟缓和更少的激动，以及更少的内疚感和更大的缺乏洞察力。结论：血管抑制的症状与可能损害纹状体-苍白球-丘脑-皮质通路和其他区域的病变一致。血管性抑郁的概念可为脑血管病的防治研究、血管性抑郁的发病过程及抗抑郁药物的选择提供动力。
OBJECTIVE The authors' goal was to examine the clinical presentation of a group of depressed elderly patients with clinically defined risk factors for vascular depression compared with a group of elderly depressed patients without such risk factors. METHOD Cognitive deficits, disability, and depressive symptoms were examined in 33 consecutively recruited elderly patients defined as having vascular depression and 32 patients defined as having nonvascular depression according to their scores on the Cumulative Illness Rating Scale-Geriatrics. RESULTS The patients with vascular depression had greater overall cognitive impairment and disability than those with nonvascular depression. Fluency and naming were more impaired in patients with vascular depression, and they had more retardation and less agitation as well as less guilt feelings and greater lack of insight. CONCLUSIONS The symptoms of vascular depression are consistent with lesions that may damage striato-pallido-thalamo-cortical pathways and other areas. The concept of vascular depression can provide the impetus for investigations of prevention and treatment of cerebrovascular disease and for studies of the course of vascular depression and selection of antidepressants.