Prognostic Value of Pro-Inflammatory Neutrophils and C-Reactive Protein in Cancer Patient With Coronavirus Disease 2019: A Multi-Center, Retrospective Study.
Prognostic Value of Pro-Inflammatory Neutrophils and C-Reactive Protein in Cancer Patient With Coronavirus Disease 2019: A Multi-Center, Retrospective Study.
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促炎性中性粒细胞和 C 反应蛋白对 2019 年冠状病毒病癌症患者的预后价值：一项多中心回顾性研究
DOI：
10.3389/fphar.2020.576994
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发表时间：
2020
影响因子：
5.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Zhang B;Yu Y;Hubert SM;Zhang Y;Lu J;Liu S;Xie F;Zhao L;Lei X;Deng W;Chen J;Li Y
背景：当前，新型冠状病毒病2019 （COVID-19）疫情迅速席卷全球。炎症细胞因子与COVID-19患者的严重程度和预后相关。然而，促炎因子在COVID-19癌症患者中的预后价值尚不清楚。方法：采用多中心、回顾性、横断面研究方法，选取湖北省5家新冠肺炎定点三级医院，于2020年1月1日至2020年4月30日选取112例癌症合并新冠肺炎患者和105例非癌症合并新冠肺炎患者。通过单变量和多变量logistic回归模型确定促炎因子对疾病严重程度和临床不良结局的风险评估。结果：112例恶性肿瘤新冠肺炎患者中，危重40例（35.7%），不幸死亡18例（16.1%）。单因素和多因素分析表明，血红蛋白水平、促炎中性粒细胞和c反应蛋白（CRP）可作为影响COVID-19严重程度的独立因素；同时，促炎中性粒细胞和CRP可作为死亡临床不良结局的独立影响因素。同时观察中性粒细胞和CRP的动态变化，与未发生癌症的COVID-19患者相比，癌症合并COVID-19患者的中性粒细胞计数和CRP水平更高。结论：在癌症合并COVID-19患者中，促炎中性粒细胞和CRP显著升高表明病情危重、临床转归不良，且与未患癌症的COVID-19患者相比，促炎中性粒细胞和CRP的不良作用更大，这可能是导致癌症合并COVID-19患者病情危重、临床转归不良的原因。
Background: At present, the epidemic of the novel coronavirus disease 2019 (COVID-19) has quickly engulfed the world. Inflammatory cytokines are associated with the severity and outcomes of patients with COVID-19. However, the prognostic value of pro-inflammatory factors in cancer patients with COVID-19 are unknown. Methods: A multi-center, retrospective, cross-sectional study, based on five designated tertiary hospitals for the treatment of COVID-19 in Hubei Province, China. 112 cancer patients with COVID-19, and 105 COVID-19 patients without cancer were enrolled in the study between January 1st, 2020 and April 30th, 2020. The risk assessment of pro-inflammatory factors for disease severity and clinical adverse outcomes was identified by univariable and multivariable logistic regression models. Results: Of the 112 cancer patients with COVID-19, 40 (35.7%) patients were in critical condition and 18 (16.1%) patients died unfortunately. Univariate and multivariate analysis demonstrated that hemoglobin level and pro-inflammatory neutrophils and C-reactive protein (CRP), can be used as independent factors affecting the severity of COVID-19; Meanwhile, pro-inflammatory neutrophils and CRP can be used as an independent influencing factor for adverse clinical outcome of death. Moreover, the dynamic changes of neutrophils and CRP were also presented, and compared with COVID-19 patients without cancer, cancer patients with COVID-19 showed higher neutrophil counts and CRP levels. Conclusion: In cancer patients with COVID-19, the significant increase in pro-inflammatory neutrophils and CRP indicated a more critical illness and adverse clinical outcome, and pro-inflammatory neutrophils and CRP played a greater adverse role compare with COVID-19 patients without cancer, which may be the cause of critical illness and adverse clinical outcomes of cancer patients with COVID-19.
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
8.8
作者：
Liu, Fang;Li, Lin;Zhou, Xiang
通讯作者：
Zhou, Xiang
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
COVID-19感染的癌症患者的临床特征：中国武汉市三家医院的回顾性病例研究
影响因子：
50.5
作者：
Zhang, L.;Zhu, F.;Zhou, M.
通讯作者：
Zhou, M.