MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women
MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women
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MAPK和ERK多态性与中国女性PCOS风险相关
DOI：
10.18632/oncotarget.22153
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发表时间：
2017-11-21
期刊：
影响因子：
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通讯作者：
Wen, Juan
中科院分区：
文献类型：
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作者：
Hu, Lingmin;Zhang, Yiting;Wen, Juan
在这项病例对照研究中，我们分析了 MEK1、MEK2、ERK1 和 ERK2 基因中 8 个 RegulomeDB 注释的单核苷酸多态性 (SNP) 与多囊卵巢综合征 (PCOS) 之间的关联。 Logistic回归分析表明MEK1 rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], P = 0.012)、ERK2 rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], P = 0.040)和ERK2 rs5999521 (OR = 0.66 [95% CI: 0.51-0.86]，P = 0.002）与 PCOS 风险相关，无需调整年龄和体重指数。此外，当这三种多态性结合时，PCOS 风险随着等位基因剂量的增加而增加 (Ptrend = 0.001)。这些发现表明，关键 MAPK 和 ERK 基因的遗传变异会导致中国女性患 PCOS 风险。
In this case-control study, we analyzed the association between eight RegulomeDB-annotated single nucleotide polymorphisms (SNPs) in the MEK1, MEK2, ERK1 and ERK2 genes and polycystic ovarian syndrome (PCOS). Logistic regression analysis demonstrated that MEK1 rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], P = 0.012), ERK2 rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], P = 0.040) and ERK2 rs5999521 (OR = 0.66 [95%CI: 0.51-0.86], P = 0.002) were associated with PCOS risk without adjusting for age and body mass index. Moreover, PCOS risk increased with allele dosage when these three polymorphisms were combined (Ptrend = 0.001). These findings suggest that genetic variants in key MAPK and ERK genes contribute to PCOS risk in Chinese women.