Merlin: hanging tumor suppression on the Rac.
Merlin: hanging tumor suppression on the Rac.
复制标题
Merlin：在Rac上挂肿瘤抑制。
DOI：
10.1016/s0962-8924(01)02128-6
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发表时间：
2001
影响因子：
19
通讯作者：
Gutmann,DH
中科院分区：
文献类型：
--
作者：
Sherman,LS;Gutmann,DH
癌症可能是由于控制细胞周期进程、细胞内信号和细胞外信号转导的许多异常引起的。对控制细胞生长调控的关键事件的许多见解来自对遗传性癌症综合征中突变的基因产物的研究。最近对神经纤维瘤病2(NF2)肿瘤抑制基因的研究表明，这种负生长调节因子可能通过调节生长因子和细胞外基质(ECM)信号来触发rac1依赖的细胞骨架相关过程。在本文中，我们根据这些和相关的新发现，提出了一个关于NF2蛋白(Merlin)功能的分子模型。
Cancer can result from any number of abnormalities in the control of cell-cycle progression, intracellular signaling and transduction of extracellular cues. Many insights into the crucial events that govern the regulation of cell growth have derived from studies of the gene products mutated in inherited cancer syndromes. Recent work on the neurofibromatosis 2 (NF2) tumor suppressor gene suggests that this negative growth regulator might function by modulating growth factor and extracellular matrix (ECM) signals that trigger Rac1-dependent cytoskeleton-associated processes. In this article, we propose a molecular model for NF2 protein (merlin) function in the light of these and related new findings.