Promotion of metastasis of C3H mouse mammary carcinoma by local hyperthermia.
Promotion of metastasis of C3H mouse mammary carcinoma by local hyperthermia.
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DOI：
10.1038/bjc.1978.246
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发表时间：
1978-10
影响因子：
8.8
通讯作者：
Abdelaal, A S
中科院分区：
文献类型：
--
作者：
Walker, A;McCallum, H M;Wheldon, T E;Nias, A H;Abdelaal, A S
HYPERTHERMIA, local and systemic, is receiving increasing attention as a possible form oftherapy in cancer treatment, either alone or in combination with drugs or radiation. This interest derives from the demonstration of experimental tumour cure by hyperthermia (Crile, 1963; Dickson & Muckle, 1972; Hahn, 1974) and from evidence for the preferential sensitivity of hypoxic cells (Robinson et al., 1974; Dewey et al., 1977) suggesting the use of hyperthermia as a potentiator in clinical radiotherapy. However, enhanced dissemination of the Yoshida sarcoma in rats has been reported (Dickson & Ellis 1974, 1976) as a result of local heating at temperatures inadequate for complete tumour destruction. Yerushalmi (1977) failed to observe promotion of metastasis of the Lewis lung carcinoma by local heating, but noted earlier appearance of pulmonary metastases after total body hyperthermia of mice. We have examined the response to hyperthermia of an infrequently metastasizing transplantable carcinoma in the C3H mouse, whose response to radiation has been described elsewhere (Abdelaal and Nias, 1978) and here we report a dramatic promotion of metastasis by local heating, administered in time-temperature combi-
