Teucvisins A-E, Five New neo-Clerodane Diterpenes from Teucrium viscidum
Teucvisins A-E, Five New neo-Clerodane Diterpenes from Teucrium viscidum
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DOI：
10.1248/cpb.c13-00990
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发表时间：
2014-05-01
影响因子：
1.7
通讯作者：
Kong, Ling-yi
中科院分区：
文献类型：
--
作者：
Lv, Hua-wei;Luo, Jian-guang;Kong, Ling-yi
从芫荽（Teucrium visidum）全株中分离得到2个新的新克罗烷二萜类化合物teucvisins A和B(1,2)， 3个新的19-非克罗烷二萜类化合物teucvisins C-E（3-5）和10个已知成分（6-15）。对所有分离株进行了脂多糖（LPS）诱导的RAW264.7巨噬细胞产生一氧化氮的抑制活性评估。结果表明，化合物11和15具有中等抑制作用，IC50值分别为21.9和22.4 μ m。
Two new neo-clerodane diterpenoids, teucvisins A and B (1, 2), and three new 19-nor-neoclerodane diterpenoids, teucvisins C-E (3-5), together with ten known constituents (6-15) were isolated from the whole plants of Teucrium viscidum. All the isolates were evaluated for their inhibitory activities of lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages. The results indicated that compounds 11 and 15 showed moderate inhibition with an IC50 value of 21.9 and 22.4 mu m, respectively.