Depressive Symptoms Differentially Predict Neurocognition in Latinx and Non-Hispanic White People Living with HIV.
Depressive Symptoms Differentially Predict Neurocognition in Latinx and Non-Hispanic White People Living with HIV.
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DOI：
10.1017/s1355617720000855
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发表时间：
2021-03
期刊：
影响因子：
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通讯作者：
Rivera Mindt M
中科院分区：
文献类型：
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作者：
Morris EP;Byrd D;Summers AC;Tureson K;Guzman V;Crook CL;Rivera Mindt M
抑郁症在艾滋病毒感染者（PLWH）中很常见，并可能导致神经认知功能障碍。PLWH的抑郁症状通常仅通过评估认知/情感症状来衡量。然而，拉丁裔成年人往往以躯体/功能的方式表达抑郁症状，这通常不会在PLWH的抑郁症评估中被捕获。考虑到拉丁裔成年人面临的不成比例的艾滋病毒负担，研究表达的抑郁症状的变化是否差异预测拉丁裔和非西班牙裔白色PLWH之间的神经认知结果是必不可少的。这项横断面研究包括140名PLWH（71%拉丁裔; 72%男性; M年龄=47.1±8.5岁; M教育=12.6±2.9岁），他们完成了一项全面的神经认知成套测验、成人阅读韦氏测验（WTAR）和贝克抑郁量表-II（BDI-II）。使用人口统计学调整的T分数测量神经认知性能。计算快速筛查（认知/情感项目）评分（BDI-FS）和非FS评分（BDI-NFS;躯体/功能项目）的BDI-II领域评分。线性回归显示，BDI-NFS显著预测了Latinx组的整体神经认知功能和处理速度（ps<.05），因此身体/功能症状越高，表现越差。在非西班牙裔白色组中，认知/情感症状显著预测处理速度（p= 0.02），更多的症状预测更好的性能。种族和每个BDI分项评分的相互作用项表明，具有较高认知/情感症状的拉丁裔参与者在执行功能方面表现较差。拉丁裔和非西班牙裔白色PLWH的抑郁症状差异预测神经认知性能。在对文化和种族日益多样化的艾滋病毒携带者进行研究和干预时，应考虑到这些差异。
Depression is common in people living with HIV (PLWH) and can contribute to neurocognitive dysfunction. Depressive symptoms in PLWH are often measured by assessing only cognitive/affective symptoms. Latinx adults, however, often express depressive symptoms in a somatic/functional manner, which is not typically captured in assessments of depression among PLWH. Given the disproportionate burden of HIV that Latinx adults face, examining whether variations in expressed depressive symptoms differentially predict neurocognitive outcomes between Latinx and non-Hispanic white PLWH is essential. This cross-sectional study included 140 PLWH (71% Latinx; 72% Male; M Age=47.1±8.5 years; M Education=12.6±2.9 years) who completed a comprehensive neurocognitive battery, Wechsler Test of Adult Reading (WTAR), and Beck Depression Inventory-II (BDI-II). Neurocognitive performance was measured using demographically-adjusted T-scores. BDI-II domain scores were computed for the Fast-Screen (cognitive/affective items) score (BDI-FS) and non-FS score (BDI-NFS; somatic/functional items). Linear regressions revealed that the BDI-NFS significantly predicted global neurocognitive function and processing speed in the Latinx group (ps<.05), such that higher physical/functional symptoms predicted worse performance. In the non-Hispanic white group, the cognitive/affective symptoms significantly predicted processing speed (p=.02), with more symptoms predicting better performance. Interaction terms of ethnicity and each BDI sub-score indicated that Latinx participants with higher cognitive/affective symptoms performed worse on executive functioning. Depressive symptoms differentially predict neurocognitive performance in Latinx and non-Hispanic white PLWH. These differences should be considered when conducting research and intervention among the increasingly culturally and ethnically diverse population of PLWH.