CYTOSKELETAL ROLE IN THE CONTRACTILE DYSFUNCTION OF HYPERTROPHIED MYOCARDIUM
CYTOSKELETAL ROLE IN THE CONTRACTILE DYSFUNCTION OF HYPERTROPHIED MYOCARDIUM
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DOI：
10.1126/science.8097594
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发表时间：
1993-04-30
期刊：
影响因子：
56.9
通讯作者：
COOPER, G
中科院分区：
文献类型：
--
作者：
TSUTSUI, H;ISHIHARA, K;COOPER, G
收缩压负荷引起的心肌肥厚常导致原因不明的收缩功能障碍。在本研究中，压力负荷增加了心肌细胞骨架的微管成分，这是观察到的细胞收缩功能障碍的原因。微管和收缩异常的联系是持久的，因此可能有意义的恶化，最初的代偿性心脏肥大到充血性心力衰竭。
Cardiac hypertrophy in response to systolic pressure loading frequently results in contractile dysfunction of unknown cause. In the present study, pressure loading increased the microtubule component of the cardiac muscle cell cytoskeleton, which was responsible for the cellular contractile dysfunction observed. The linked microtubule and contractile abnormalities were persistent and thus may have significance for the deterioration of initially compensatory cardiac hypertrophy into congestive heart failure.