Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia
Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia
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DOI：
10.1172/jci143011
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发表时间：
2021-02-01
影响因子：
15.9
通讯作者：
Palmer, Jerry P.
中科院分区：
文献类型：
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作者：
Gubitosi-Klug, Rose A.;Braffett, Barbara H.;Palmer, Jerry P.
背景我们调查了糖尿病控制和并发症试验/糖尿病干预和并发症流行病学（DCCT/EDIC）研究参与者的残余β细胞功能，这些参与者平均病程为35年。在4小时混合餐耐受试验期间测量血清C肽。在无应答者（餐后所有C肽值均为0.2）、中间（>0.03至= 0.003至0.03 nmol/L）中探索与代谢结局和并发症的关系，我们观察到严重低血糖的患病率有临床意义的降低。
BACKGROUND. We investigated residual beta cell function in Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study participants with an average 35-year duration of type 1 diabetes mellitus (T1DM).METHODS. Serum C-peptide was measured during a 4-hour mixed-meal tolerance test. Associations with metabolic outcomes and complications were explored among nonresponders (all C-peptide values after meal 0.2), intermediate (>0.03 to = 0.003 to 0.03 nmol/L, we observed clinically meaningful reductions in the prevalence of severe hypoglycemia.