Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients
Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients
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DOI：
10.1016/s0304-3940(98)00453-4
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发表时间：
1998-06-26
影响因子：
2.5
通讯作者：
Soininen, H
中科院分区：
文献类型：
--
作者：
Hiltunen, M;Mannermaa, A;Soininen, H
对丁酰胆碱酯酶K （BChE-K）变异基因的等位基因频率的检测显示，芬兰晚发性阿尔茨海默病（AD）患者无论是整体还是携带载脂蛋白E （ApoE4）的epsilon 4等位基因的AD患者亚群中，等位基因频率均未增加。相比之下，携带ApoE4等位基因的75岁以下芬兰AD患者组与非痴呆对照组相比，BChE-K等位基因频率显著降低（chi(2), P < 0.05）。AD组和对照组同时携带BChE-K和ApoE4等位基因的比例分别为14%和41% (chi(2), P < 0.01；优势比0.22,95% CI 0.07-0.71)。这些结果与先前对英国AD患者的研究相反，该研究认为BChE-K和ApoE4基因协同作用。(C) 1998爱思唯尔科学爱尔兰有限公司版权所有。
Examination of the allelic frequency of the butyrylcholinesterase K (BChE-K) variant gene revealed no increase among Finnish late-onset Alzheimer's disease (AD) patients either as a whole or among a subset of AD patients carrying the epsilon 4 allele of apolipoprotein E (ApoE4). In contrast, BChE-K allele frequency was significantly reduced in the Finnish AD patient group under 75 years of age carrying the ApoE4 allele when compared to the non-demented controls (chi(2), P < 0.05). The proportion of subjects with both BChE-K and ApoE4 alleles was 14% and 41% in AD and control groups, respectively (chi(2), P < 0.01; odds-ratio 0.22, 95% CI 0.07-0.71). These results are in contrast to a previous study on English AD patients, in which the genes for BChE-K and ApoE4 were suggested to act in synergy. (C) 1998 Elsevier Science Ireland Ltd. AII rights reserved.