Postsynaptic endocannabinoid release is critical to long-term depression in the striatum
Postsynaptic endocannabinoid release is critical to long-term depression in the striatum
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DOI：
10.1038/nn832
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发表时间：
2002-05-01
影响因子：
25
通讯作者：
Lovinger, DM
中科院分区：
文献类型：
--
作者：
Gerdeman, GL;Ronesi, J;Lovinger, DM
纹状体在运动控制和习惯形成中起着关键作用。皮质向纹状体输入的发育和功能被认为是由皮质纹状体谷氨酸能突触的活动依赖性可塑性所调节。在此我们表明，一种纹状体突触可塑性形式——长时程抑制（LTD）的诱导依赖于CB1大麻素受体的激活。通过阻断细胞内源性大麻素的摄取可促进LTD，并且花生四烯酸乙醇胺（AEA）的突触后负载可产生突触前抑制。因此，纹状体LTD所必需的内源性大麻素很可能作为一种逆行信使在突触后释放。这些发现表明内源性大麻素在习惯形成和运动控制所必需的回路中诱导长时程突触可塑性方面具有新的作用。
The striatum functions critically in movement control and habit formation. The development and function of cortical input to the striatum are thought to be regulated by activity-dependent plasticity of corticostriatal glutamatergic synapses. Here we show that the induction of a form of striatal synaptic plasticity, long-term depression (LTD), is dependent on activation of the CB1 cannabinoid receptor. LTD was facilitated by blocking cellular endocannabinoid uptake, and postsynaptic loading of anandamide (AEA) produced presynaptic depression. The endocannabinoid necessary for striatal LTD is thus likely to be released postsynaptically as a retrograde messenger. These findings demonstrate a new role for endocannabinoids in the induction of long-term synaptic plasticity in a circuit necessary for habit formation and motor control.