Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects
Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects
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DOI：
10.1161/01.hyp.0000113081.42868.f4
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发表时间：
2004-02-01
期刊：
影响因子：
8.3
通讯作者：
Aviv, A
中科院分区：
文献类型：
--
作者：
Benetos, A;Gardner, JP;Aviv, A
最近的研究表明，端粒较短的人患动脉病变的几率更高，心血管疾病的死亡率也更高。作为一个群体，高血压患者患心血管疾病的风险增加。然而，一些高血压患者比其他人更容易发生动脉粥样硬化病变。本研究的主要目的是研究端粒长度（以白细胞表达）与高血压男性颈动脉粥样硬化斑块之间的关系。研究人员分析了163名接受治疗的高血压男性志愿者的数据，这些人都是参加免费医学检查的志愿者。b超检查颈动脉颅外斑块。端粒长度是从白细胞中提取的DNA样本中测量的。本研究结果显示，有颈动脉斑块的高血压患者端粒长度比无斑块的高血压患者短（8.17 +/- 0.07 kb比8.46 +/- 0.07 kb, P < 0.01）。多变量分析表明，除了年龄外，端粒长度是颈动脉斑块存在的重要预测因子。这项研究的结果表明，慢性高血压是动脉粥样硬化病变的主要危险因素，白细胞端粒长度较短与颈动脉粥样硬化的易感性增加有关。
Recent studies have shown that individuals with shorter telomeres present a higher prevalence of arterial lesions and higher risk of cardiovascular disease mortality. As a group, patients with high blood pressure are at an increased risk for cardiovascular diseases. However, some hypertensive patients are more prone than others to atherosclerotic lesions. The main objective of this study was to examine the relationship between telomere length, as expressed in white blood cells, and carotid artery atherosclerotic plaques in hypertensive males. Data from 163 treated hypertensive men who were volunteers for a free medical examination were analyzed. Extracranial carotid plaques were assessed with B-mode ultrasound. Telomere length was measured from DNA samples extracted from white blood cells. The results of this study show that telomere length was shorter in hypertensive men with carotid artery plaques versus hypertensive men without plaques (8.17 +/- 0.07 kb versus 8.46 +/- 0.07 kb; P < 0.01). Multivariate analysis showed that in addition to age, telomere length was a significant predictor of the presence of carotid artery plaques. The findings from this study suggest that in the presence of chronic hypertension, which is a major risk factor for atherosclerotic lesions, shorter telomere length in white blood cells is associated with an increased predilection to carotid artery atherosclerosis.