Multiple sclerosis and the role of immune cells.
Multiple sclerosis and the role of immune cells.
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DOI：
10.5493/wjem.v4.i3.27
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发表时间：
2014-08-20
期刊：
影响因子：
--
通讯作者：
Maghazachi, Azzam A
中科院分区：
文献类型：
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作者：
Hoglund, Rune A;Maghazachi, Azzam A
多发性硬化症 (MS) 是一种复杂的疾病，其发病机制涉及许多不同的免疫细胞，特别是 T 细胞作为最受认可的细胞类型。最近，人们还研究了先天免疫系统对疾病的影响。因此，免疫系统细胞在改善或加剧疾病方面发挥着至关重要的作用。遗传和环境因素以及病因和发病机制对于多发性硬化症的发生至关重要。将深入了解 T 细胞、B 细胞、自然杀伤细胞和树突状细胞在 MS 和动物模型实验性自身免疫性脑脊髓炎中所发挥的作用。了解当前治疗方式的作用机制应有助于开发新的治疗工具来治疗这种疾病和其他自身免疫性疾病。
Multiple sclerosis (MS) is a complex disease with many different immune cells involved in its pathogenesis, and in particular T cells as the most recognized cell type. Recently, the innate immune system has also been researched for its effect on the disease. Hence, cells of the immune system play vital roles in either ameliorating or exacerbating the disease. The genetic and environmental factors, as well as the etiology and pathogenesis are of utmost importance for the development of MS. An insight into the roles play by T cells, B cells, natural killer cells, and dendritic cells in MS and the animal model experimental autoimmune encephalomyelitis, will be presented. Understanding the mechanisms of action for current therapeutic modalities should help developing new therapeutic tools to treat this disease and other autoimmune diseases.