Chronic recording and electrochemical performance of Utah microelectrode arrays implanted in rat motor cortex
Chronic recording and electrochemical performance of Utah microelectrode arrays implanted in rat motor cortex
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DOI：
10.1152/jn.00181.2018
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发表时间：
2018-10-01
影响因子：
2.5
通讯作者：
Cogan, Stuart F.
中科院分区：
文献类型：
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作者：
Black, Bryan J.;Kanneganti, Aswini;Cogan, Stuart F.
多位点植入式电极阵列作为一种工具，以了解皮层网络的连接和可塑性。此外，它们使电刺激能够驱动可塑性，研究运动/感觉映射，或提供控制脑机接口的网络输入。神经行为啮齿动物模型由于其相对低的成本和易于训练而在运动皮层损伤和恢复以及听觉/视觉线索恢复的研究中普遍存在。因此，了解相关电极阵列在啮齿动物模型中的慢性性能非常重要。在这份报告中，我们评估的慢性记录和电化学性能的16通道犹他州电极阵列。在6个月的时间内，在大鼠运动皮层中进行临床前/临床皮层记录和刺激的最新技术水平。单个单位活性电极产率从52.8 +/- 10.0（第1周）降至13.4 +/- 5.1%（第24周）。同样，在同一时间段内，所有阵列的所有电极上记录的单个单位总数从106个减少到15个。电化学阻抗谱和阴极电荷存储容量的平行测量表现出显着的变化，与随着时间的推移，电解质泄漏途径的发展相一致的电化学特性。此外，最大阴极电位偏移的测量结果表明，只有相对较小比例的电极（植入后1周和24周时为10-35%）能够输送相关电流（4 nC/ph时为20 μ A），而不会超过负或正电化学电位限值。总的来说，我们的研究结果表明，主要是非生物的故障模式，包括机械线断裂以及导电和绝缘基板的降解。新&值得注意的是，多位点植入式电极阵列可作为记录皮层网络活动的工具，并使电刺激能够驱动可塑性或提供网络反馈。啮齿动物模型在这些领域的使用是普遍的。我们评估了大鼠运动皮层中16通道犹他州电极阵列在6个月内的慢性记录和电化学性能。我们主要观察到非生物失效模式，表明机械电线断裂和/或绝缘退化。
Multisite implantable electrode arrays serve as a tool to understand cortical network connectivity and plasticity. Furthermore, they enable electrical stimulation to drive plasticity, study motor/sensory mapping, or provide network input for controlling brain-computer interfaces. Neurobehavioral rodent models are prevalent in studies of motor cortex injury and recovery as well as restoration of auditory/visual cues due to their relatively low cost and ease of training. Therefore, it is important to understand the chronic performance of relevant electrode arrays in rodent models. In this report, we evaluate the chronic recording and electrochemical performance of 16-channel Utah electrode arrays. the current state-of-the-art in pre-/clinical cortical recording and stimulation, in rat motor cortex over a period of 6 mo. The single-unit active electrode yield decreased from 52.8 +/- 10.0 (week 1) to 13.4 +/- 5.1% (week 24). Similarly, the total number of single units recorded on all electrodes across all arrays decreased from 106 to 15 over the same time period. Parallel measurements of electrochemical impedance spectra and cathodic charge storage capacity exhibited significant changes in electrochemical characteristics consistent with development of electrolyte leakage pathways over time. Additionally, measurements of maximum cathodal potential excursion indicated that only a relatively small fraction of electrodes (10-35% at 1 and 24 wk postimplantation) were capable of delivering relevant currents (20 mu A at 4 nC/ph) without exceeding negative or positive electrochemical potential limits. In total, our findings suggest mainly abiotic failure modes, including mechanical wire breakage as well as degradation of conducting and insulating substrates.NEW & NOTEWORTHY Multisite implantable electrode arrays serve as a tool to record cortical network activity and enable electrical stimulation to drive plasticity or provide network feedback. The use of rodent models in these fields is prevalent. We evaluated chronic recording and electrochemical performance of 16-channel Utah electrode arrays in rat motor cortex over a period of 6 mo. We primarily observed abiotic failure modes suggestive of mechanical wire breakage and/or degradation of insulation.