Methylation muscles into transcription factor silencing.
Methylation muscles into transcription factor silencing.
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DOI：
10.4161/trns.20914
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Taneja R
中科院分区：
文献类型：
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作者：
Bharathy N;Taneja R
转录因子 MyoD 是骨骼肌分化的主要调节因子。 G9a 是一种主要参与组蛋白 H3 赖氨酸 9 二甲基化 (H3K9me2) 的酶，它可以甲基化 MyoD，这一发现确定了染色质修饰剂调节非组蛋白底物转录活性以控制细胞分化程序的先前未被认识到的机制。
The transcription factor MyoD is a master regulator of skeletal muscle differentiation. The finding that G9a, an enzyme principally involved in histone H3 lysine 9 di-methylation (H3K9me2), methylates MyoD, identifies previously unappreciated mechanisms by which chromatin modifiers regulate the transcriptional activity of non-histone substrates to control cellular differentiation programs.