Bone bonding in bioactive glass ceramics combined with a new synthesized agent TAK-778.
Bone bonding in bioactive glass ceramics combined with a new synthesized agent TAK-778.
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与新型合成剂 TAK-778 结合的生物活性玻璃陶瓷中的骨粘合。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
T. Nakamura
中科院分区：
文献类型：
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作者：
H. Kato;M. Neo;J. Tamura;T. Nakamura
我们研究了TAK-778（一种促进成骨细胞分化的新型合成3-苯并噻庚因衍生物）在兔胫骨骨与生物活性玻璃陶瓷植入物结合中的刺激作用。将由含磷灰石-硅灰石的玻璃陶瓷制成的光滑表面矩形板（15 x 10 x 2 mm）双侧植入家兔胫骨近端干骺端。将含TAK-778的缓释微胶囊装入一侧肢体的髓腔中，将未处理的微胶囊装入对侧肢体中作为配对对照。在植入后4、8和16周，使用分离试验和未脱钙标本的组织学检查评价骨/植入物界面的结合。在第4 - 16周期间，两组的拉伸失效载荷均增加;在植入后的每个时间点，TAK-778给药组的拉伸失效载荷均显著大于对照组。在组织学上，TAK-778处理的样本显示，与未处理的样本相比，主要在髓腔中的活性新骨形成更大，植入物与骨之间的结合更广泛。本研究的结果表明，将促进骨形成的TAK-778添加到生物活性玻璃陶瓷植入物中可显著加速骨与植入物的沉积，并改善界面处的结合过程。这将有助于建立骨科陶瓷植入物与周围骨组织的早期和更强的结合。
We studied the stimulatory effects of TAK-778, a new synthetic 3-benzothiepin derivative that promotes osteoblast differentiation, in the bonding of bone to bioactive glass ceramic implants in rabbit tibiae. Smooth-surfaced, rectangular plates (15 x 10 x 2 mm) made of apatite-wollastonite-containing glass ceramic were implanted bilaterally into the proximal metaphyses of rabbit tibiae. Sustained-release microcapsules containing TAK-778 were packed into the medullary cavity in one limb and untreated microcapsules were packed into the contralateral limb to serve as a paired control. At 4, 8, and 16 weeks after implantation, bonding at the bone/implant interfaces was evaluated using a detaching test and histological examination of undecalcified specimens. The tensile failure load increased during weeks 4 to 16 in both groups; the tensile failure load in the TAK-778-treated group was significantly greater than that in the control group at each interval after implantation. Histologically, the TAK-778-treated specimens showed greater active new bone formation mainly in the medullary cavity and more extensive bonding between the implant and bone than the untreated specimens. The results of this study suggest that adding the bone formation-promoting TAK-778 to bioactive glass ceramic implants may significantly accelerate bone apposition to the implants and improve the bonding process at the interface. This would help to establish earlier and stronger bonding of orthopedic ceramic implants to the surrounding bone tissue.
通过转化生长因子-β 促进骨向内生长。
DOI：
10.2106/00004623-199508000-00001
发表时间：
1995
期刊：
The Journal of bone and joint surgery. American volume
影响因子：
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作者：
Sumner,DR;Turner,TM;Purchio,AF;Gombotz,WR;Urban,RM;Galante,JO
通讯作者：
Galante,JO