Mind the Gap: Sex Bias in Basic Skin Research
Mind the Gap: Sex Bias in Basic Skin Research
复制标题
DOI：
10.1038/jid.2015.298
复制
发表时间：
2016-01-01
影响因子：
6.5
通讯作者：
Paller, Amy S.
中科院分区：
文献类型：
--
作者：
Kong, Betty Y.;Haugh, Isabel M.;Paller, Amy S.
鉴于美国国立卫生研究院最近提出在临床前研究中平衡使用雄性和雌性细胞和动物的建议，我们探讨了皮肤研究中是否存在性别偏见。我们调查了 2012 年至 2013 年的 802 篇皮肤病学研究文章。60% 的论文没有提供有关研究细胞或动物性别的信息。在已知性别的角质形成细胞中，70%是男性。很少有研究比较雄性与雌性细胞或动物。性别的披露和比较研究有助于我们理解性别差异的生物学基础。解决临床前研究中的性别差异可为后续临床试验设计提供信息并促进个体化治疗。
Given the recent National Institutes of Health proposal for balanced use of male and female cells and animals in preclinical studies, we explored whether sex bias exists in skin research. We surveyed 802 dermatological research articles from 2012 through 2013. No information about the sex of studied cells or animals was provided in 60% of papers. Among keratinocytes of known sex, 70% were male. Few studies compared male versus female cells or animals. Disclosure of sex and comparative studies contribute to our understanding of the biologic basis of sex differences. Addressing sex-specific differences in preclinical research informs subsequent clinical trial design and promotes individualized therapy.