HYPOTHALAMUS IN PARKINSON DISEASE
HYPOTHALAMUS IN PARKINSON DISEASE
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DOI：
10.1002/ana.410030207
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发表时间：
1978-01-01
影响因子：
11.2
通讯作者：
FORNO, LS
中科院分区：
文献类型：
--
作者：
LANGSTON, JW;FORNO, LS
本文对30例经病理证实的特发性帕金森综合征患者的下丘脑进行了系统检查。使用路易体形成作为神经细胞变性的标志，我们观察到每个下丘脑检查异常。在13个可以单独识别的下丘脑核团中，没有一个免于路易体变性。结节乳头核和下丘脑外侧核和后核的平均路易体计数最高（分别为16、9和3），它们也是最常受累的核团。这些发现可能有助于解释帕金森病患者的自主神经和内分泌异常。
The hypothalamus was systematically examined in 30 patients with pathologically documented idiopathic parkinsonism. Using Lewy body formation as a marker for nerve cell degeneration, we observed abnormalities in every hypothalamus examined. Of the thirteen hypothalamic nuclei that could be individually identified, none were exempt from Lewy body degeneration. The tuberomamillary nucleus and the lateral and posterior hypothalamic nuclei demonstrated the highest average Lewy body counts (16, 9, and 3, respectively); they were also the most frequently involved nuclei. These findings may aid in interpretation of the autonomic and endocrine abnormalities in patients with Parkinson disease.