Stereocontrolled synthesis of (+)-boronolide
Stereocontrolled synthesis of (+)-boronolide
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DOI:
10.1021/ol026665i
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发表时间:
2002-10-03
期刊:
影响因子:
5.2
通讯作者:
Yeh, VSC
中科院分区:
文献类型:
--
作者:
Trost, BM;Yeh, VSC
[GRAPHICS]Boronolide was synthesized stereoselectively from hydroxyacetylfuran 5 and valeraldehyde 6 using a novel dizinc aldol catalyst. Ring closing metathesis provides the lactone ring. The synthesis requires 12 steps and proceeds in 26% overall yield.