Primary Sjogren's syndrome with chronic tubulointerstitial nephritis and lymphadenopathy mimicking IgG4-related disease
Primary Sjogren's syndrome with chronic tubulointerstitial nephritis and lymphadenopathy mimicking IgG4-related disease
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DOI：
10.3109/14397595.2013.844303
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发表时间：
2015-07-01
影响因子：
2.2
通讯作者：
Yamaguchi, Yutaka
中科院分区：
文献类型：
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作者：
Kawano, Mitsuhiro;Suzuki, Yasunori;Yamaguchi, Yutaka
我们描述了一个62岁的女性干燥综合征（SS）表现为肾小管间质性肾炎（TIN）和淋巴结病模仿IgG 4相关疾病（IgG 4-RD）。计算机断层扫描显示多个肿胀的淋巴结。最大淋巴结活检显示反应性淋巴结病伴密集IgG 4阳性浆细胞（IgG 4 + PC）浸润。肾活检显示慢性富含浆细胞的TIN伴IgG 4 + PC浸润。本例提示免疫球蛋白G4染色在SS和IgG 4-RD的鉴别诊断中并不总是支持IgG 4-RD的诊断。
We describe a 62-year-old woman with Sjogren's syndrome (SS) presenting with tubulointerstitial nephritis (TIN) and lymphadenopathy mimicking IgG4-related disease (IgG4-RD). Computed tomography revealed multiple swollen lymph nodes. Biopsy of the largest lymph node showed reactive lymphadenopathy with dense IgG4 positive plasma cell (IgG4 + PC) infiltration. Renal biopsy showed chronic plasma cell-rich TIN with IgG4 + PC infiltration. This case suggests that Immunoglobulin G4 immunostaining does not always support the diagnosis of IgG4-RD in the differential diagnosis between SS and IgG4-RD.