Development of rear-impeller axial-flow blood pump for realization of axial flow blood pump installed at aortic valve position
Development of rear-impeller axial-flow blood pump for realization of axial flow blood pump installed at aortic valve position
复制标题
后叶轮轴流血泵的研制，实现轴流血泵安装在主动脉瓣位置
DOI：
10.1111/aor.13476
复制
发表时间：
2019
期刊：
影响因子：
2.4
通讯作者：
Mitamura Y.
中科院分区：
文献类型：
--
作者：
Okamoto E;Yano T;Inoue Y;Shiraishi Y;Yambe T;Mitamura Y.
在本研究中，开发了后叶轮轴流血泵（RIAFBP）来实现跨阀轴流心室辅助装置（VAD），该装置由后叶轮血泵和聚合物单膜主动脉瓣（如水母瓣膜）组成。RIAFBP的马达安装在左心室，其叶轮放置在主动脉瓣位置。在原型RIAFBP中，电机的旋转是由聚乙烯套管维持的。RIAFBP长50毫米，直径19.6毫米。微型RIAFBP具有与原型相同的结构；然而，它采用陶瓷轴承和鳍形轴承，以提高耐力和减少血液停滞。微型RIAFBP长63毫米，直径12毫米。两种riafbp均采用33%甘油溶液进行体外实验。原型RIAFBP在12 000 rpm转速下，泵扬程为100 mm Hg，最大泵出流量为8.5 L/min。在21 600转/分钟的转速下，小型RIAFBP在70毫米汞柱的泵扬程下达到7升/分钟。综上所述，微型RIAFBP具有足够的泵性能来实现反阀轴向VAD。
In this study, rear‐impeller axial flow blood pumps (RIAFBP) were developed to realize a trans‐valve axial ventricular assist device (VAD) which consists of the latter blood pump and a polymer monomembrane aortic valve, such as the jellyfish valve. The motor of the RIAFBP is installed in the left ventricle, and its impeller is placed at the aortic valve position. In the prototype RIAFBP, the rotation of the motor is sustained by polyethylene bushings. The RIAFBP has a length of 50 mm and diameter of 19.6 mm. The miniature RIAFBP has the same construction as that of the prototype; however, it employs a ceramic bearing and fin bearing to improve endurance and to reduce blood stagnation. The miniature RIAFBP has a length of 63 mm and diameter of 12 mm. Both RIAFBPs were examined by an in vitro experiment using a 33% glycerin solution. The prototype RIAFBP achieved a maximum pump outflow of 8.5 L/min against a pump head of 100 mm Hg at a rotational speed of 12 000 rpm. The miniature RIAFBP achieved 7 L/min against a pump head of 70 mm Hg at a rotational speed of 21 600 rpm. In conclusion, the miniature RIAFBP has enough pump performance to realize the trans‐valve axial VAD.