Atrial natriuretic peptide, right atrial pressure, and sodium excretion rate in the rat.
Atrial natriuretic peptide, right atrial pressure, and sodium excretion rate in the rat.
复制标题
大鼠心房钠尿肽、右心房压和钠排泄率。
DOI：
10.1152/ajprenal.1987.253.5.f969
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Stein,JH
中科院分区：
文献类型：
--
作者：
Fried,TA;Ayon,MA;McDonald,G;Lau,A;Inagami,T;Stein,JH
本研究探讨了右心房压力（RAP），尿流率，钠排泄率和血浆心钠素（ANP）水平之间的关系后，急性林格氏扩张。对两组大鼠的RAP进行监测，并将球囊导管置于其胸下腔静脉。在一组中，球囊保持回缩，而在第二组中，球囊在体积扩张期间充盈，试图防止RAP升高。当球囊保持回缩时，峰值RAP为7.3 ± 0.8 mmHg，球囊导管充盈组为3.5 ± 0.6 mmHg（P <0.005）。相应的峰值ANP水平为682 +/- 140和223 +/- 40 pg/ml。RAP峰值与ANP水平呈显著相关（r = 0.754; P <0.05）。球囊导管的膨胀显著降低了尿流率和尿钠排泄率。最后一组动物在体积扩张前输注了200微升含有ANP抗体的兔血清。抗体处理的动物的尿流量和钠排泄率显著低于非抗体处理的对照大鼠。我们的结论是，ANP是一个因素，使大鼠排泄急性林格氏扩张。
This study examined the relationship between right atrial pressure (RAP), urine flow rate, sodium excretion rate, and plasma atrial natriuretic peptide (ANP) levels after an acute Ringer expansion. Two groups of rats had their RAP monitored and balloon catheters placed in their thoracic inferior venae cavae. In one group the balloon remained deflated, and in the second group the balloon was inflated during the volume expansion in an attempt to prevent the rise in RAP. The peak RAP was 7.3 +/- 0.8 mmHg when the balloon remained deflated and 3.5 +/- 0.6 mmHg in the group with the balloon catheter inflated (P less than 0.005). The corresponding peak ANP levels were 682 +/- 140 and 223 +/- 40 pg/ml. There was a significant correlation between the peak RAP and ANP levels (r = 0.754; P less than 0.05). The inflation of the balloon catheter significantly decreased the urine flow rate and the urine sodium excretion rate. A final group of animals had 200 microliters of rabbit serum containing antibody to ANP infused before the volume expansion. The antibody-treated animals had significantly lower urine flow and sodium excretion rates than nonantibody-treated control rats. We conclude that ANP is one of the factors which allows the rat to excrete an acute Ringer expansion.