Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women
Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women
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DOI：
10.3945/ajcn.2009.28206
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发表时间：
2010-01-01
影响因子：
7.1
通讯作者：
Innis, Sheila M.
中科院分区：
文献类型：
--
作者：
Friesen, Russell W.;Innis, Sheila M.
背景：花生四烯酸（ARA）、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）在膜甘油磷脂中是重要的。妊娠期较高的母体血液ARA、EPA和DHA浓度分别与较高的母体向胎儿转移ARA、EPA和DHA相关，这强调了妊娠期母体脂肪酸状态的重要性。就像在大脑中一样，红细胞（RBC）乙醇胺磷酸甘油酯（epg）富含浆磷脂原、ARA和DHA。目的：探讨近期孕妇饮食中n-6 （ω -6）和n-3 （ω -3）脂肪酸摄入量与红细胞EPGs和磷脂酰胆碱中n-6和n-3脂肪酸的关系。设计：受试者为105名健康的加拿大孕妇（孕36周）。采用食物频率问卷法估算脂肪酸摄入量，并采集空腹静脉血样本。结果：DHA和EPA摄入量与红细胞EPG和磷脂酰胆碱浓度呈正相关（rho分别为0.309和0.369,P < 0.001）和EPA (rho分别为0.391和0.228,P < 0.001)，与红细胞EPG 22:4 n-6和22:5 -6呈负相关（P < 0.001）。在红细胞中，亚油酸（LA, 18:2 n-6）浓度与DHA、EPA和ARA分别呈负相关，在epg中（r = -0.432, P < 0.01; r = -0.201, P < 0.04; r = -0.303, P < 0.01）和磷脂酰胆碱（r = -0.460, -0.490和-0.604，P均< 0.01）。结论：膜脂肪酸受脂肪酸底物的数量和平衡的影响。我们的研究结果表明，LA与ARA、EPA和DHA之间存在竞争性相互作用，没有证据表明高LA会增加ARA。在我们的人群中有生化指标表明DHA是有限的。该试验已注册为临床试验。网址：NCT00620672。m J . clinn [2010]；91: 23-31。
Background: Arachidonic (ARA), eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids are important in membrane glycerophospholipids. Higher maternal blood ARA, EPA, and DHA concentrations in gestation are associated with higher maternal-to-fetal transfer of ARA, EPA, and DHA, respectively, which emphasizes the importance of maternal fatty acid status in gestation. As in the brain, red blood cell (RBC) ethanolamine phosphoglycerides (EPGs) are high in plasmalogen, ARA, and DHA.Objective: We determined the relation between dietary n-6 (omega 6) and n-3 (omega-3) fatty acid intakes and n-6 and n-3 fatty acids in RBC EPGs and phosphatidylcholine in near-term pregnant women.Design: The subjects were 105 healthy Canadian pregnant (36 wk gestation) women. Fatty acid intakes were estimated by food-frequency questionnaire, and fasting venous blood samples were collected.Results: DHA and EPA intakes were positively associated with RBC EPG and phosphatidylcholine concentrations of DHA (rho = 0.309 and 0.369, respectively; P < 0.001) and EPA (rho = 0.391 and 0.228, respectively; P < 0.001) and inversely associated with RBC EPG 22: 4n-6 and 22: 5-6 (P < 0.001). In RBCs, concentrations of linoleic acid (LA, 18: 2n-6) were inversely associated with DHA, EPA, and ARA, respectively, in EPGs (r = -0.432, P < 0.01; r = -0.201, P < 0.04; and r = -0.303, P < 0.01) and phosphatidylcholine (r = -0.460, -0.490, and -0.604; P < 0.01 for all).Conclusions: Membrane fatty acids are influenced by the amount and balance of fatty acid substrates. Our results suggest the competitive interaction of LA with ARA, EPA, and DHA, with no evidence that higher LA increases ARA. Biochemical indicators to suggest that DHA is limiting are present in our population. This trial was registered at clinicaltrials. gov as NCT00620672. Am J Clin Nutr 2010; 91: 23-31.