THE INFLUENCE OF AGE AND BLOOD-PRESSURE ON THE HEMODYNAMIC AND HUMORAL RESPONSE TO HEAD-UP TILT
THE INFLUENCE OF AGE AND BLOOD-PRESSURE ON THE HEMODYNAMIC AND HUMORAL RESPONSE TO HEAD-UP TILT
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DOI：
10.1111/j.1532-5415.1989.tb05684.x
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发表时间：
1989-06-01
影响因子：
6.3
通讯作者：
HOEFNAGELS, WHL
中科院分区：
文献类型：
--
作者：
JANSEN, RWMM;LENDERS, JWM;HOEFNAGELS, WHL
据报道，老年人体位性低血压是常见的。然而，这些研究包括机构和或多或少的残疾人.此外，体位性低血压可能与基线血压有关。在这项研究中，年龄和血压的影响，对血液动力学和血浆儿茶酚胺反应的直立性应激在年轻和老年正常血压和高血压的健康受试者进行了调查。在血压正常和高血压的老年人中，倾斜时的血压反应百分比与血压正常的年轻人没有显著差异。我们测得收缩压轻微下降，舒张压轻微升高。与血压正常的年轻受试者相比，高血压的年轻患者表现出舒张压反应增强，收缩压没有下降。两组老年人的心率增幅均低于年轻人。倾斜后去甲肾上腺素增加的百分比在老年高血压患者中显著低于老年血压正常者和年轻高血压患者。高血压的存在与血压下降有关，但年龄对倾斜期间血压的变化没有影响。在这组健康的老年受试者中，当考虑到整个倾斜试验的血压过程时，没有明显的直立性低血压。
It has been reported that postural hypotension in the elderly is common. However, these studies included institutionalized andmore or less disabled persons. Furthermore, postural hypotension may be related to baseline blood pressure. In this study, the influence of age and blood pressure on the hemodynamic and plasma catecholamine responses to orthostatic stress was investigated in young and old normotensive and hypertensive healthy subjects. In normotensive and hypertensive elderly persons, the percentage blood presure responses during tilt were not significantly different from that seen in young normotensives. We measured a slight decrease of systolic blood pressure and a slight increase of diastolic blood pressure. The hypertensive young patients showed an enhanced diastolic blood pressure response with no fall in systolic blood pressure, in contrast to the normotensive young subjects. Both elderly groups had a lower incease of heart rate than the young subjects. The percentage increase in norepinephrine after tilting was significantly lower in elderly hypertensives than in elderly normotensives and young hypertensives. The presence of hypertension was associated with a decrease in blood pressure, but age had no influence on the change in blood pressure during tilt. In this group of healthy elderly subjects, there was no significantly orthostatic hypotension when the blood pressure course of the entire tilt test was taken into account.