Serum cortisol-to-cortisone ratio and 11-deoxycortisol are associated with hypertension and blood pressure in Chinese rural population: a cross sectional study
Serum cortisol-to-cortisone ratio and 11-deoxycortisol are associated with hypertension and blood pressure in Chinese rural population: a cross sectional study
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中国农村人口血清皮质醇与可的松比值和 11-脱氧皮质醇与高血压和血压相关：一项横断面研究
DOI：
10.1097/hjh.0000000000003028
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发表时间：
2021-10
影响因子：
4.9
通讯作者：
Huo Wenqian
中科院分区：
文献类型：
--
作者：
Song Yu;Nie Luting;Wei D;an;Liu Pengling;Fan Keliang;Zhang Li;Wang Mian;Wang Lulu;Liao Wei;Kang Ning;Xu Qingqing;Wang Juan;Mao Zhenxing;Wang Chongjian;Huo Wenqian
目的：本研究旨在探讨皮质醇/可的松比值（F/E）和11-脱氧皮质醇（S）与中国农村人群高血压和血压的关系。方法：选取河南省农村队列研究的6233名被试。血清皮质醇（F），可的松（E），和S使用液相色谱-串联质谱法进行了评估。采用广义线性模型（GLM）和Logistic回归模型分析F、E、F/E和S与血压和高血压的关系。此外，性别特异性的协会进行了评估。结果如下：血清F、F/E和S与收缩压（SBP）、舒张压（DBP）和脉压（PP）呈正相关，而E与SBP和PP呈负相关。F和E与高血压患病率无统计学显著相关性，而F/E和S与高血压呈正相关[F/E和S的比值比（OR）和95%置信区间（CI）分别为1.28（1.13，1.44）和1.10（1.04，1.17）。此外，高F/E和S的组合与高血压显著相关。随着血清F、F/E、S浓度的增加，血压指标及高血压患病率均增加（P均<0.05）。 女性的F/E与SBP的正相关性强于男性，且仅女性的F/E与高血压呈正相关（P均<0.05）。 结论：血清F/E、S与高血压及血压呈正相关。此外，它们的组合对高血压具有协同作用。此外，F和F/E与高血压和血压的关系具有性别特异性。
Supplemental Digital Content is available in the text Objective: The present study aimed to investigate the associations of cortisol-to-cortisone ratio (F/E) and 11-deoxycortisol (S) in hypertension and blood pressure among Chinese rural population. Methods: A total of 6233 participants from the Henan Rural Cohort Study were included. Serum cortisol (F), cortisone (E), and S were assessed using liquid chromatography–tandem mass spectrometry. Generalized linear model (GLM) and logistic regression model were performed to assess the associations of F, E, F/E, and S with blood pressure and hypertension. Moreover, the sex specificity of the associations was assessed. Results: Serum F, F/E, and S were positively associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP), while E was negatively associated with SBP and PP. There were no statistically significant associations of F and E with the prevalence of hypertension, while F/E and S were positively associated with hypertension [odds ratios (ORs) and 95% confidence intervals (CIs)] of F/E and S were 1.28 (1.13, 1.44) and 1.10 (1.04, 1.17), respectively. Also, the combination of high F/E and S was significantly associated with hypertension. The blood pressure indicators and the prevalence of hypertension increased with an incremental in the serum concentration of F, F/E, and S (all Ptrend < 0.05). In addition, the positive association between F/E and SBP was stronger in women than that in men, and F/E was strongly positively associated with hypertension only in women (all Pinteraction < 0.05). Conclusion: Serum F/E and S were positively associated with hypertension and blood pressure. Additionally, their combination has a synergistic effect on hypertension. Moreover, the associations of F and F/E with hypertension and blood pressure were in a sex-specific manner.
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DOI：
10.1097/00041552-199303000-00015
发表时间：
1993-03
影响因子：
3.2
作者：
J. Blumenfeld
通讯作者：
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DOI：
10.1038/s41581-019-0244-2
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期刊：
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影响因子：
168.9
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Lu, Jiapeng;Lu, Yuan;Jiang, Lixin
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DOI：
10.1016/j.beem.2006.07.001
发表时间：
2006-09-01
影响因子：
7.4
作者：
Hammer, Fabian;Stewart, Paul M.
通讯作者：
Stewart, Paul M.