CENTRAL AND PERIPHERAL CHEMOREFLEX LOOP GAIN IN NORMAL AND CAROTID BODY-RESECTED SUBJECTS
CENTRAL AND PERIPHERAL CHEMOREFLEX LOOP GAIN IN NORMAL AND CAROTID BODY-RESECTED SUBJECTS
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DOI：
10.1152/jappl.1979.46.4.843
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发表时间：
1979-01-01
影响因子：
3.3
通讯作者：
WIBERG, DM
中科院分区：
文献类型：
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作者：
BELLVILLE, JW;WHIPP, BJ;WIBERG, DM
在7名正常（N）志愿者和4名接受双侧颈动脉体切除术（CBR）的志愿者中，在常氧和低氧（PETO 2 = 53 mmHg）条件下维持PETO 2 [潮气末CO2张力]恒定的情况下，产生5分钟高碳酸血症步骤（PETCO 2 [潮气末CO2张力] = 48 mmHg）。通过将包括外周和中枢增益、时间延迟和时间常数的2室模型拟合到数据来研究缓解反应。缺氧增加了N例受试者中从暂时性高碳酸血症到暂时性高碳酸血症的速度和幅度，这与外周化学感受器中的CO2-O2相互作用一致。在常氧和缺氧条件下，颈动脉体切除者的通气反应均较慢。在正常和颈动脉体切除受试者中，缺氧增加了关闭瞬态的速度。缺氧明显增加外周增益N受试者，这种增益是没有显着不同的零颈动脉体切除组。颈动脉体切除受试者的慢（中央）成分的增益约为正常对照组的一半。外周化学感受器可影响中枢呼吸控制机制的功能。
In 7 normal (N) volunteers and 4 who had bilateral carotid body resection (CBR), 5-min hypercapnic steps (to PETCO2 [end tidal CO2 tension] = 48 torr) were generated with PETO2 [end tidal O2 tension] maintained constant under euoxic and hypoxic (PETO2 = 53 torr) conditions. The ventilatory response was studied by fitting a 2-compartment model that included peripheral and central gains, time delays and time constants to the data. Hypoxia increased the speed and magnitude of the ventilatory on-transient to hypercapnia in N subjects, consistent with CO2-O2 interaction at the peripheral chemoreceptors. Ventilatory responses were slower in the carotid body-resected subjects in euoxia and hypoxia. Hypoxia increased the speed of the off-transient in normal and carotid body-resected subjects. Hypoxia markedly increased peripheral gain in N subjects; this gain was not significantly different from zero in the carotid body-resected group. The gain of the slow (central) component in carotid body-resected subjects was approximately half that of the normal controls. The peripheral chemoreceptors may influence the functioning of the central respiratory control mechanisms.