Lack of sex differences in anxiety behaviors during precipitated benzodiazepine withdrawal in rats.
Lack of sex differences in anxiety behaviors during precipitated benzodiazepine withdrawal in rats.
复制标题
大鼠在苯二氮卓类药物快速戒断过程中的焦虑行为缺乏性别差异。
DOI：
10.1016/s0031-9384(98)00286-8
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发表时间：
1999
影响因子：
2.9
通讯作者：
Wilson,MA
中科院分区：
文献类型：
--
作者：
Stock,H;Ford,K;Biscardi,R;Wilson,MA
据报道，非沉淀性苯二氮卓类（BZ）戒断会增加大鼠的焦虑水平。本实验确定了性别或激素状态是否会调节大鼠在BZ戒断过程中焦虑相关行为的假定变化。用空的或填充地西泮（DZ）的硅橡胶胶囊对完整和性腺切除的雄性和雌性大鼠进行4周处理。将动物用BZ拮抗剂氟马西尼（R 0 15 -1788; 5 mg/kg，i. p.）或载体，并立即置于高架十字迷宫上。在10分钟的行为测试后，将大鼠断头并收集躯干血以测量皮质酮和性腺激素水平。在BZ快速戒断期间，大鼠的开臂时间百分比显著降低;然而，这一发现被活动水平的显著降低所混淆（例如，闭臂输入和全臂输入）。与溶剂对照组动物相比，BZ停药未显著减弱开放臂进入百分比，这排除了药物诱导的活动水平变化。总的来说，本实验的结果表明，与对照动物相比，BZ的突然戒断不会显著增加焦虑水平。
Nonprecipitated benzodiazepine (BZ) withdrawal has been reported to increase anxiety levels in rats. The present experiment determined if gender or hormonal status would modulate putative changes in anxiety-related behaviors during precipitated BZ withdrawal in rats. Intact and gonadectomized male and female rats were treated for 4 weeks with empty or diazepam (DZ)-filled silastic capsules. Animals were injected with the BZ antagonist flumazenil (RO15-1788; 5 mg/kg, i.p.) or vehicle, and immediately placed on the elevated plus-maze. Following the 10-min behavioral test, rats were decapitated and trunk blood was collected to measure corticosterone and gonadal hormone levels. During precipitated BZ withdrawal rats showed significantly decreased percent open-arm time; however, this finding was confounded by a significant decrease in activity levels (e.g., closed-arm entries and total-arm entries). Precipitated BZ withdrawal did not significantly attenuate percent open-arm entries, which factors out drug-induced changes in activity levels, compared to vehicle control animals. Overall, the results of this experiment suggest that precipitated BZ withdrawal does not significantly increase anxiety levels when compared to control animals.