Association of central adiposity with prediabetes and decreased insulin sensitivity in rural Chinese normal-weight and overweight women.
Association of central adiposity with prediabetes and decreased insulin sensitivity in rural Chinese normal-weight and overweight women.
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中国农村正常体重和超重女性中枢性肥胖与糖尿病前期和胰岛素敏感性降低的关系。
DOI：
10.1016/j.metabol.2009.10.029
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Wang,Xiaobin
中科院分区：
文献类型：
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作者：
Yu,Yunxian;Venners,ScottA;Wang,Binyan;Brickman,WendyJ;Zimmerman,Donald;Li,Zhiping;Wang,Liuliu;Liu,Xue;Tang,Genfu;Xing,Houxun;Xu,Xiping;Wang,Xiaobin
这项研究调查了在正常体重(体重指数23 kg/m2)和超重(体重指数≥23 kg/m2)的中国农村妇女中，中心性肥胖是否与糖尿病前期和胰岛素敏感性(IS)降低有关。采用双能X线骨密度仪测定4071名20~60岁农村女性的体脂百分比、下半身脂肪百分比和躯干脂肪百分比，以及一般脂肪变量(BMI和腰围)，以探讨肥胖与糖尿病前期的关系。此外，在正常糖耐量和超重的糖耐量正常的女性中，都测试了肥胖与IS的相关性。BMI与体脂百分比、腰围高度相关，与%LF、%Tf弱相关。在正常和超重的女性中，高%Tf(%Tf的上四分位)和低%Lf(%Lf的下三个四分位)都与较高的糖尿病前期患病率相关。与低%Tf的正常体重女性相比，高%Tf的女性无论是否超重(优势比[95%可信区间]=1.6[1.3-2.0])或不超重(优势比[95%可信区间]=1.5[1.2-2.0])，患糖尿病前期的几率都有类似的增加。同样，在3280名糖耐量正常的女性中，无论体重状态(正常或超重)，高%Tf与空腹胰岛素、2小时口服葡萄糖耐量试验胰岛素和胰岛素抵抗的稳态模型评估相关。在相对苗条的中国农村妇女中，高%Tf与糖尿病前期风险增加有关，而无论体重状况(正常或超重)，低%Tf与糖尿病前期风险增加有关。
This study investigated whether high central adiposity was associated with prediabetes and decreased insulin sensitivity (IS) in both normal-weight (body mass index [BMI] <23 kg/m2) and overweight (BMI ≥23 kg/m2) rural Chinese women. Adipose variables measured by dual-energy x-ray absorptiometry (percentage body fat, percentage lower-body fat [%LF], and percentage trunk fat [%TF]) and general adipose variables (BMI and waist circumference) were used for examining the association of adiposity with prediabetes among 4071 rural Chinese women aged 20 to 60 years. Furthermore, the association of adiposity with IS was tested in both normal- and overweight women with normal glucose tolerance. BMI was highly correlated with percentage body fat and waist circumference, but was weakly correlated with %LF and %TF. Both high %TF (top quartile of %TF) and low %LF (lower 3 quartiles of %LF) were associated with higher prevalence of prediabetes in both normal- and overweight women. Compared with normal-weight women in low %TF, the odds of prediabetes were similarly increased for women with high %TF regardless of whether they were overweight (odds ratio [95% confidence interval] = 1.6 [1.3-2.0]) or not (odds ratio [95% confidence interval] = 1.5 [1.2-2.0]). Similarly, among 3280 women with normal glucose tolerance, high %TF was associated with increased fasting insulin, 2-hour oral glucose tolerance test insulin, and homeostasis model assessment of insulin resistance regardless of weight status (normal or overweight). Among relatively lean, rural Chinese women, high %TF was associated with increased odds of prediabetes and lower IS regardless of weight status (normal or overweight).