Plasma levels of diethylcarbamazine and their effects on implanted microfilariae of Brugia pahangi in rats.
Plasma levels of diethylcarbamazine and their effects on implanted microfilariae of Brugia pahangi in rats.
复制标题
二乙基卡马嗪的血浆水平及其对大鼠体内植入的彭亨丝虫微丝蚴的影响。
DOI：
10.1292/jvms.59.961
复制
发表时间：
1997
影响因子：
1.2
通讯作者：
Y. Aoki
中科院分区：
文献类型：
--
作者：
Y. Horii;Y. Aoki
采用气相色谱法测定血浆二乙基卡马嗪（DEC）水平，并与大鼠腹腔注射200 mg/kg DEC后微丝丝虫血症的变化进行比较。在DEC治疗前1天，通过静脉内植入2×10(5)彭亨布鲁丝虫微丝蚴(mf)人工诱导微丝蚴血症。用DEC治疗的大鼠在30分钟内表现出循环中的mf数快速且显着降低，持续4小时，然后迅速增加。 DEC 似乎可以直接对大鼠彭亨伊伯克霍尔德氏菌微丝丝血症产生短暂但显着的抑制作用。
Plasma level of diethylcarbamazine (DEC) was measured by using gas chromatography and was compared to the changes of microfilaremia after an intraperitoneal injection with 200 mg/kg of DEC in rats. The microfilaremia was induced artificially by an intravenous implantation with 2 x 10(5) Brugia pahangi microfilariae (mf) 1 day before DEC treatment. The rats treated with DEC showed a rapid and significant decrease in mf number in the circulation within 30 min, continued for 4 hr, and then increased rapidly. DEC seemed to cause transient but significant suppression of microfilaremia of B. pahangi in rats directly.