Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity
Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity
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DOI：
10.1152/ajpheart.00975.2005
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发表时间：
2006-07-01
影响因子：
4.8
通讯作者：
Sugimachi, Masaru
中科院分区：
文献类型：
--
作者：
Michikami, Daisaku;Kamiya, Atsunori;Sugimachi, Masaru
尽管电针可降低交感神经活动（SNA）和动脉压（AP），但电针对动脉压力反射的影响仍有待系统分析。我们使用由神经弧和外周弧组成的平衡图研究了电针足三里对动脉压力反射的影响。在麻醉、迷走神经切断和去主动脉神经的兔子中，我们分离了颈动脉窦，并将颈内动脉窦压力 (CSP) 从 40 毫米汞柱改变为 160 毫米汞柱，增量为 20 毫米汞柱/分钟，同时记录心脏 SNA 和 AP。采用电针足三里，脉冲持续时间为 5 ms，频率为 1 Hz。使用的电流是可见肌肉抽搐所需的最小阈值电流的 10 倍，并确定为 4.8 +/- 0.3 mA。电针 8 分钟降低了 SNA 和 AP (n = 6)。它将神经弧（即 CSP-SNA 关系）转移到较低的 SNA，但不影响外周弧（即 SNA-AP 关系）（n = 8）。由神经弧和外周弧的交点确定的闭环工作点的 SNA 和 AP 分别从 100 +/- 4 到 80 +/- 9 任意单位和从 108 +/- 9 到 99 +/- 8 mmHg 下降（每个 P < 0.005）。腓骨去神经术通过电针消除了神经弧的移位（n = 6）。将脉冲持续时间减少到 < 2.5 ms 消除了 SNA 和 AP 减少的影响。总之，短期电针将神经弧重置为较低的 SNA，从而在压力反射闭环条件下将工作点移向较低的 AP 和 SNA。
Although electroacupuncture reduces sympathetic nerve activity (SNA) and arterial pressure (AP), the effects of electroacupuncture on the arterial baroreflex remain to be systematically analyzed. We investigated the effects of electroacupuncture of Zusanli on the arterial baroreflex using an equilibrium diagram comprised of neural and peripheral arcs. In anesthetized, vagotomized, and aortic-denervated rabbits, we isolated carotid sinuses and changed intra-carotid sinus pressure (CSP) from 40 to 160 mmHg in increments of 20 mmHg/min while recording cardiac SNA and AP. Electroacupuncture of Zusanli was applied with a pulse duration of 5 ms and a frequency of 1 Hz. An electric current 10 times the minimal threshold current required for visible muscle twitches was used and was determined to be 4.8 +/- 0.3 mA. Electroacupuncture for 8 min decreased SNA and AP (n = 6). It shifted the neural arc (i.e., CSP-SNA relationship) to lower SNA but did not affect the peripheral arc (i.e., SNA-AP relationship) (n = 8). SNA and AP at the closed-loop operating point, determined by the intersection of the neural and peripheral arcs, decreased from 100 +/- 4 to 80 +/- 9 arbitrary units and from 108 +/- 9 to 99 +/- 8 mmHg (each P < 0.005), respectively. Peroneal denervation eliminated the shift of neural arc by electroacupuncture (n = 6). Decreasing the pulse duration to < 2.5 ms eliminated the effects of SNA and AP reduction. In conclusion, short-term electroacupuncture resets the neural arc to lower SNA, which moves the operating point toward lower AP and SNA under baroreflex closed-loop conditions.