Autism Is a Prenatal Disorder: Evidence From Late Gestation Brain Overgrowth
Autism Is a Prenatal Disorder: Evidence From Late Gestation Brain Overgrowth
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DOI：
10.1002/aur.2036
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发表时间：
2018-12-01
期刊：
影响因子：
4.7
通讯作者：
Roux, Sylvie
中科院分区：
文献类型：
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作者：
Bonnet-Brilhault, Frederique;Rajerison, Toky A.;Roux, Sylvie
这项回顾性研究旨在使用产前和产后头部生长参数来确定自闭症谱系障碍（ASD）患者非典型大脑发育的关键时期。样本包括80名1995年以后出生的白人、无关、特发性ASD患者。在妊娠中期和晚期获得胎儿超声参数（头围[HC]、腹围和股骨长度）。还收集了出生时的HC和12月龄和24月龄的产后参数。在第二个（闭经20-26周）和第三个（闭经28-36周）妊娠期，通过HC评估突出头部过度生长。胎仔身体参数的正常生长表明头部过度生长不是因为整体身体过度生长。此外，出生后的结果复制以前和报告头部过度生长。自闭症患者非典型脑发育的一个关键时间窗口被假设为从闭经的第22周开始开始。这一时期对于皮层分层和神经胶质活化至关重要。一个病理生理级联建议候选基因和环境因素之间的相互作用。(C)2018年国际自闭症研究学会，Wiley Periodicals，Inc。
This retrospective study aimed to specify the critical period for atypical brain development in individuals with autism spectrum disorder (ASD) using prenatal and postnatal head growth parameters. The sample consisted of 80 Caucasian, unrelated, idiopathic patients with ASD born after 1995. Fetal ultrasound parameters (head circumference [HC], abdominal circumference, and femur length) were obtained during the second and third trimesters of gestation. HC at birth and postnatal parameters at 12 and 24 months of age were also collected. Head overgrowth, assessed by HC, was highlighted during the second (20-26 weeks of amenorrhea) and third (28-36 weeks of amenorrhea) trimesters. Normal growth of body fetal parameters indicated that head overgrowth was not because of overall body overgrowth. Moreover, postnatal results replicated previously and reported head overgrowth. A critical time window for atypical brain development in autism is hypothesized to begin from the 22nd week of amenorrhea. This period is critical for cortical lamination and glial activation. A pathophysiological cascade is suggested with interactions between candidate genes and environmental factors. (C) 2018 International Society for Autism Research, Wiley Periodicals, Inc.