Scalable magnet geometries enhance tumour targeting of magnetic nano-carriers
Scalable magnet geometries enhance tumour targeting of magnetic nano-carriers
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DOI：
10.1016/j.matdes.2020.108610
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发表时间：
2020-06-01
影响因子：
8.4
通讯作者：
Lythgoe, Mark F.
中科院分区：
文献类型：
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作者：
Mohseni, Matin;Connell, John J.;Lythgoe, Mark F.
靶向药物递送系统旨在增加靶组织或器官内的治疗效果，同时减少与全身递送相关的脱靶毒性。磁性药物靶向已被证明是一种有效的策略，通过使用磁场和氧化铁载体在体内操纵治疗剂。然而，目前磁铁的有效靶向范围将这种方法限制在小动物实验或人体的浅表部位。在这里，我们生产临床上可平移的磁体设计，能够增加组织暴露于磁场和场梯度，导致载流子积累增加。首先使用简单的血管流动系统在体外评估氧化铁纳米颗粒捕获效率。其次，使用一系列不同的磁体设计在体内评价了这些颗粒在磁性靶向之后的累积。我们观察到，与传统的1T盘式磁铁相比，我们的定制磁铁的有效靶向深度增加了4倍。最后，我们表明，这种磁铁是很容易扩展到人体大小的比例，并有可能在人体的特定位置，以100纳米的颗粒高达7厘米的深度。(C)2020年，任作家。爱思唯尔有限公司出版
Targeted drug delivery systems aim to increase therapeutic effect within the target tissue or organ, while reducing off-target toxicity associated with systemic delivery. Magnetic drug targeting has been shown to be an effective strategy by manipulating therapeutics inside the body using a magnetic field and an iron oxide carrier. However, the effective targeting range of current magnets limits this method to small animal experiments or superficial parts of the human body. Here we produce clinically translatable magnet designs capable of increasing exposure of tissue to magnetic fields and field gradients, leading to increased carrier accumulation. The iron oxide nanoparticle capturing efficiency was first assessed in vitro using a simple vascular flow system. Secondly, accumulation of these particles, following magnetic targeting, was evaluated in vivo using a range of different magnet designs. We observed that our bespoke magnet produced a 4-fold increase in effective targeting depth when compared to a conventional 1 T disk magnet. Finally, we show that this magnet is readily scalable to human size proportions and has the potential to target 100 nm particles up to a depth of 7 cm at specific locations of human body. (C) 2020 The Authors. Published by Elsevier Ltd.